摘要
本文旨在观察１∶２０万肾上腺素对丁布氟芬液行术后硬膜外腔病人自控镇痛（ＰＣＥＡ）效应的影响。选择ＡＳＡⅠ～Ⅱ级，硬膜外腔麻醉下行中下腹部手术病人４０例，随机分为两组，Ⅰ组（ｎ＝２０）：丁布氟芬液１００ｍｌ＋０．１％肾上腺素０．５ｍｌ（即含１∶２０万肾上腺素）；Ⅱ组（ｎ＝２０）：丁布氟芬液１００ｍｌ＋ＮＳ０．５ｍｌ。用双盲法观察两组病人术后镇痛２４小时用药量、镇痛效果、血压、心率变化及嗜睡发生率。结果：２４小时用药量、ＶＡＳ评分、嗜睡发生率，两组相比无明显差异（Ｐ＞０．０５）；各组内镇痛前、后血压无明显改变（Ｐ＞０．０５）；心率变化：Ｉ组镇痛后比镇痛前增快（Ｐ＜０．０５）。结果表明：１∶２０万肾上腺素对丁布氟芬液术后ＰＣＥＡ无增强效应。
The effect of 1∶200,000 adrenaline in a combined analgesic solution (buprenorphine hydrochloride 7.0μg/ml+droperidol 10μg/ml+fentanyl 4μg/ml+0.125% bupivacaine) on patient controlled epidural analgesia (PCEA)was observed.40 ASAⅠ～Ⅱ patients received middle and low abdominal surgery with epidural anesthesia were randomly divided into two groups. Group Ⅰ(n=20): combined analgesic solution 100ml+0.1% adrenaline 0.5ml. Group Ⅱ(n=20): combined analgesic solution 100ml+0.9% normal saline solution 0.5ml. The volume of analgesic solution, analgesic efficacy, the changes of blood pressure and heart rate, and somnolence incidence rate were investigated during 24 hours by double blind study. The result showed that there was no significant difference with 24h solution volume and somnolence incidence rate between the two groups. Heart rate increased after analgesia compared with that before analgesia in group Ⅰ(P<0.05); There were no signifcant differences of blood pressure between pre analgesia and post analgesia periods in both groups(P>0.05); VAS scores ≤2 in both groups. Conclusion: 1∶200,000 adrenaline has no potentiating effect on postoperative PCEA using a mixture of buprenorphine, droperidol, fentanyl and bupivacaine.
出处
《中国疼痛医学杂志》
CAS
CSCD
1998年第3期135-138,共4页
Chinese Journal of Pain Medicine
关键词
肾上腺素
自控镇痛
硬膜外腔
Adrenaline
Patient Controlled Epidural Analgesia
