摘要
目的探讨眩晕宁对椎基底动脉供血不足(vertebrobasilar in sufficiency,VBI)患者血清SOD、MDA及血浆内皮素、一氧化氮的影响。方法用比色法测定健康对照组、对照组、治疗组血清MDA和SOD水平,用放射免疫法测定测定血浆内皮素的变化,一氧化氮(NO)采用硝酸还原法测定。结果与健康对照组比较,对照组、治疗组血清SOD活性降低(P<0.05),MDA含量降低(P<0.05),一氧化氮(NO)降低(P<0.05),血浆内皮素水平升高(P<0.01)。应用尼莫地平(ni modip-ine,NIM)治疗的对照组虽能够降低血浆内皮素水平和升高NO,但未见SOD、MDA的变化,眩晕宁治疗组能够回升SOD活性,降低MDA含量,与健康对照组及对照组有明显差别(P<0.05,P<0.05),与对照组比较,治疗组在降低内皮素(endothe-lin,ET)和升高NO方面疗效更为显著(P<0.01)。结论眩晕宁可能通过降低氧化应激反应,降低血浆内皮素和升高NO水平,对椎基底动脉供血不足有治疗作用。
Objective To explore the effects of xuanyunning on the serum superoxide dismutase（SOD）, malondialdehyde （MDA）, plasma endothelin and nitric oxide in patients with vertebrobasilar in sufficiency. Methods The levels of SOD and MDA were measured by colorimetry, the alterations of plasma endothelin were measured by radiation immunological test and nitric oxide（NO） were measured by nitrate reduction method in control group, experimental group and xuanyunning treatment group. Results Compared with control group, the activity of SOD and nitric oxide were decreased while the content of MDA was increased in experimental group and treatment group, moreover, the level of plasma endothelin was increased in experimental group and treatment group（P〈0.01）, the elevated plasma endothelin was decreased in experimental group with nimodipine （P〈0.01）, but there were no obvious changes of SOD and MDA. The low activity of SOD and nitric oxide were increased（P〈 0.05）, while the hig content of MDA was decreased（P〈0.05）, and lower level of plasma endothelin was induced（P〈〈0.05） in xuanyunning treatment group compared with experimental group and control group（P〈0.05, P〈0.01）. Conclusion Xuanyunning improves the blood volume by lowering the reaction of oxidative stress and by lowreing the level of plasma endothelin, elevating and nitric oxide in patients with vertebrobasilar in sufficiency.
出处
《中国实用神经疾病杂志》
2010年第1期6-8,共3页
Chinese Journal of Practical Nervous Diseases
关键词
眩晕宁
椎基底动脉供血不足
内皮素
NO
超氧化物歧化酶
丙二醛
Xuanyunning
Vertebrobasilar in sufficiency
Endothelin
Nitric oxide
Superoxide dismutase
Malondialdehyde
