摘要
目的比较甘精胰岛素联合门冬胰岛素(G+A)与胰岛素泵(CSII)、常规皮下注射胰岛素(MSII)治疗2型糖尿病围手术期患者效果及安全性。方法将79例糖尿病随机分为三组:G+A组(n=27),CSII组(n=27),MSII组(n=25)。比较三种治疗方法在控制血糖水平、低血糖发生率、血糖达标时间、术前准备时间、平均住院日等方面的差异。结果G+A组血糖控制效果明显优于MSII组(P<0.01),低血糖发生率低于MSII组(P<0.01),血糖达标时间及术前准备时间及平均住院日与MSII组比较均明显缩短(P<0.01),G+A组与CSII组比较各项指标无显著差异。结论甘精胰岛素联合门冬胰岛素治疗糖尿病围手术期患者血糖控制平稳、安全,减少低血糖发生,达标迅速,减少平均住院日。
Objective To compare the therapeutic effects and safety of glargine ＋ aspart （ G ＋ A）, continuous subcutaneous insulin in- jection（CSII） by insulin pump and multiple subcutaneous insulin injection（MSII） in treatment of type 2 diabetic patients in a periopera- tire period. Methods Seventy-nine cases of type 2 diabetes mellitus were randomly assigned into three groups ： G ＋ A group（ n = 27 ）, CSII group（ n = 27）and MSII group（ n = 25 ）. The level of blood glucose, the rate of hypoglycemic episodes, the blood glucose target time, the preoperative preparation time, and the average hospitalized time were compared among three groups. Results The blood glu- cose level in G ＋ A group was significantly lower than that in MSII group（ P 〈 0.01 ）, the glucose target time, the preoperative prepara- tion time and the average hospitalized time were shorter than that in MSII group（P 〈 0.01 ）. The hypoglycemic episode in G ＋ A group was also lower than that in MSII group （ P 〈 0.01 ）. No difference was found in all data between G ＋ A group and CSII group （ P 〉 O. 05）. Conclusion Glagine plus aspart could control safety and stability of blood glucose, decrease hypoglycemic episodes, and shorten the time of blood glucose for achieving the target,the preoperative preparation time, and the average hospitalized time.
出处
《山西医科大学学报》
CAS
2010年第1期52-54,共3页
Journal of Shanxi Medical University
