摘要
目的探讨体外伤口收缩模型含成纤维细胞的胶原网架（ＦＰＣＬ）收缩的可能机理。方法利用光镜及扫描电镜对ＦＰＣＬ的收缩进行动态观察。结果ＦＰＣＬ的收缩是由成纤维细胞产生的一种牵拉力而引起，该力是一种复合式动力，由细胞突起的延伸运动与细胞浆内的收缩结构共同产生。结论ＦＰＣＬ收缩的机理支持了有关伤口收缩机理的“牵拉”
Objective To approach the mechanism of contraction of an in vitro wound contraction model fibroblast populated collagen lattice (FPCL).Methods The authors observed the process of FPCL dynamic contraction with both light microscopy and scanning electron microscopy. Results FPCL contraction is due to the traction force generated by fibroblasts. The traction force is a compound force exerted by extension of cellular pseudopod and contractile structure in cytoplasm.Conclusion The mechanism of FPCL contraction proves the theory of “traction”.
关键词
成纤维细胞
胶原网架
伤口收缩
体外模型
Fibroblast populated Collagen lattice Wound contraction In vitro model
