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哮喘动物模型中血红素加氧酶-1对调节性T淋巴细胞1抑制细胞增殖功能的影响研究 被引量：1

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摘要 哮喘是一种慢性气道炎症性疾病，由多种炎症细胞、炎症介质及细胞因子参与并相互作用引起气道组织损伤、气道重构、黏液腺增生及黏液分泌显著增加。近年来哮喘治疗的目标更趋于哮喘发病的起始阶段，
作者 蔚京京 范国权
机构地区 山西医科大学儿科系 山西医科大学微生物与免疫教研室
出处 《中国药物与临床》 CAS 2010年第1期51-53,共3页 Chinese Remedies & Clinics
关键词 哮喘治疗 血红素加氧酶-1 细胞增殖功能 T淋巴细胞 动物模型 慢性气道炎症性疾病 调节性 黏液分泌
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献10

  • 1Kobayashi H, Takeno M, Saito T, et al. Regulatory role of heine oxygenase 1 in inflammation of rheumatoid arthritis. Arthritis Rheum, 2006,54(4): 1132-1142.
  • 2Overhaus M,Moore BA,Barbato JE,et al. Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators. Am J Physiol Gastrointest Liver Physiol,2006,290(4):695- 703.
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  • 5蔚京京,钟文伟,须丽清,邵洁,李云珠,俞善昌,周光炎,夏振炜.血红素加氧酶-1介导Tr1细胞在哮喘动物模型中的免疫调节作用[J].临床儿科杂志,2009,27(1):67-71. 被引量：3
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二级参考文献1

共引文献2

同被引文献20

  • 1李馨宇,马文军,王天成,沈惠麒.胆红素的抗氧化作用及血红素加氧酶对胆红素的调控作用[J].工业卫生与职业病,2006,32(3):139-142. 被引量：12
  • 2须丽清,钟文伟,李宁丽,邵洁,李云珠,俞善昌,夏振炜.血红素加氧酶-1上调CD4^+ CD25^+ Treg foxp3表达以增强Treg的免疫抑制功能[J].现代免疫学,2006,26(6):469-476. 被引量：6
  • 3Dulak Jet al. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation, 2008, 117:231-241.
  • 4Shamloul R. The potential role of the heme oxygenase/carbon monoxide system in male sexual dysfunctions. J Sex Med, 2009, 6:324-333.
  • 5Lin PH et al. Ubiquitin-proteasome system mediates heine oxygenase-1 degradation through endoplasmic reticulum- associated degradation pathway. Biochim Biophys Acta, 2008, 1783:1826-1834.
  • 6Chen J et al. Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heine-mediated oxidative injury. Curr Neurovasc Res, 2005, 2:189-196.
  • 7Gong P et al. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. J Biol Chem, 2003, 278:29693-29700.
  • 8Chen JC et al. HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways. Cell Signal, 2006, 18:32-39.
  • 9Andersen MH et al. Identification of heme oxygenase-1- specific regulatory CD8^+ T cells in cancer patients. J Clin Invest, 2009, 119:2245-2256.
  • 10Rodella LF et al. Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes. Drug Metab Lett, 2008, 2:290-300.

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中国药物与临床
2010年 第1期

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