摘要
目的应用磁共振弥散成像技术探讨儿童胼胝体压部及枕钳角度的年龄和性别差异及其变化规律。方法90例无中枢神经系统症状及体征且颅脑磁共振检查正常的儿童(年龄5d～18岁)。按年龄分为5组:婴儿组(≤1岁),幼儿组(>1～3岁),学龄前组(>3～6岁),学龄组(>6～12岁),青春发育期组(>12～18岁)。每个年龄组内再按性别分为男、女2组。各组儿童分别行头部弥散张量成像,在各向异性值图上测量其胼胝体压部及枕钳成角角度,并对所测数据进行统计分析。结果1.婴儿组女童所测得的胝胝体压部及枕钳所成的角度值最大;随年龄增加,各角度的均值在整体上逐渐减小;但在不同年龄阶段,个别数值会出现先增大后减小。2.婴儿组所测角度在不同性别儿童均具有统计学差异;幼儿组枕钳角度、胼胝体压部最大成角在不同性别儿童间均有统计学意义;学龄前组、青春发育期组枕钳角度在性别上亦有统计学意义。3.不同性别儿童枕钳成角及胼胝体压部最小成角组间方差分析,差异具有统计学意义。4.枕钳角度及胼胝体压部最小成角与年龄存在负相关;胼胝体压部最大成角与年龄在统计学分析中无明显相关性;枕钳角度及胼胝体压部最小成角与年龄呈线性回归关系。结论胼胝体压部及枕钳成角角度存在一定的性别差异;枕钳成角及部分胼胝体压部成角随年龄的增长而减小,磁共振弥散成像技术能够用于观察儿童胼胝体压部及枕钳成角角度存在的性别和年龄差异及其变化规律。
Objective To explore the difference of angles formed in age and sex by splenium corporis callosi and occipital forceps in children using diffusion-weighted technology.Methods Ninety children（age ranged from 5 days to 18 years）without abnormal central nervous system signs and symptoms and with normal head MRI were classified into 5 groups according to their ages.The age groups were as follows：infant group（≤1 year old）,young child group（1-3 years old）,pre-school age group（3-6 years old）,school age group（6-12 years old）and adolescence group（12-18 years old）.In each age group,children were classified according to their genders.Diffusion tensor imaging（DTI）was performed in all the children＇s heads.Then the angles formed by splenium corporis callosi and occipital forceps were measured in fractional anisotropy maps.All the data were analyzed statistically.Results 1.The females in infant group had the larger angles formed by splenium corporis callosi and occipital forceps.With the age increasing,the average values of angles tended to decrease gradually.But in some age groups,the average values in some cases tended to increase before it decreased.2.A statistically significant sex difference was found in infant group.In young child group,pre-school age group and adolescence group,such difference was found in angles formed by occipital forceps.Only in young child group,difference in the maximum angles of splenium corporis callosi was found.3.There was a significant difference between age groups in the angles formed by sides of occipital forceps and the minimum angles of splenium corporis callosi through one-way analysis of variance.4.The angles of occipital forceps and the minimum angles of splenium corporis callosi both had a negative correlation with ages.They both had a linear regression to ages.But,there was no correlation between the maximum angles of splenium corporis callosi and ages.Conclusions Sex differences might exist in the angles formed by both sides of occipital forceps and splenium corporis callosi.The angles formed by sides of occipital forceps and parts of angles of splenium corporis callosi might decrease when the age increases.Diffusion-weighted technology can be used to study the age and sex difference in angles formed by splenium corporis callosi and occipital forceps in children.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2009年第24期1887-1890,共4页
Journal of Applied Clinical Pediatrics
基金
福建省科技三项高校专项基金资助(2007F5046)
关键词
枕钳
胼胝体
性别差异
磁共振
弥散
儿童
occipital forceps
corpus callosum
sex difference
magnetic resonance imaging
diffusion
child
