摘要
应用^(125)I-lipiodol抗癌乳剂经肝动脉灌注治疗不可切除的中晚期肝癌44例,取得显著的疗效,所有病例均有不同程度的症状改善,其中30例AFP阳性患者、25例术后一月完全转阴,5例AFP值下降至200ng/ml以下;术前AFP值增高(100～400ng/ml)4例患者,术后均转为阴性,20例肝区疼痛消失;18例肿瘤缩小。本法的主要特点,即将肿瘤区域的局部放疗、化疗和栓塞疗法三者结合在一起,不同环节的联合作用,起到综合抗癌的效果,为肝癌的导向治疗开辟了新的方法。
A new field of study in experimental and clinical aspects was presented using ^(125)I-Lipiodol mixed with anticancer drugs through hepatic artery to treat unresectable primary liver cancer. 44 cases with, hepatoma received this therapy with satisfactory results. On the bases of animal experiments, 44 patients were treated in this way and followed up for 3 to 36 monthes. It showed that all of the patients were improved in different extents. Of 30 cases with AFP positive, 25 cases became AFP negative within one month, AFP vales decreased obviously on 5 cases. Size of the tumor became smaller in 18 cases and stable in 22 cases. There are three effects in this method at least: First, as ^(123)I-Lipiodol could stay in tumor area for long time, it could be a source of radiation. Second, because that the anticancer drugs could atay in cancer area with high selectivity, local concentration of the drug was higher and side effects of chemotherapy were lower. Lastly, minor particles of ^(125)I-Lipiodol could remain in capillaries of tumor so that they could obstruct blood supply of tumor to achieve good mbolism therapy.
关键词
肝肿瘤
导向治疗
碘化油
阿霉素
: liver neoplasms
targeted therapy
lipiodol
adriamycin
mitomycins
