摘要
对60例流行性出血热患者测定了血清和尿β_(2-m)的变化,发现本病发热期血清β_(2-m)即明显高于正常,少尿期达高峰值,多尿期开始下降,至恢复期降至正常。血清β_(2-m)与BUN大致呈平行变化关系;重症组患者疾病前三期血清β_(2-m)均值皆高于轻症组。尿β_(2-m)含量的变化类似于血清β_(2-m)。这些结果说明本病肾小球与肾小管皆有损害。我们认为,若同时检测血清、尿β_(2-m)及BUN,则更能反映肾脏受损情况。
The changes in concentrations of serum and urinay β_2-microglobulin(β_2-m)were observed in 60 patients with epidemic hemorrhagic fever(EHF). The mean concentration of serum β_2-m was remarkably raised during the febrile phase of the illness. It reached its peak value during the oliguria phase; then decreased during polyuric phase and restored to normal range in convalescent phase. There were parallel correlation between the cencentration of serum β_2-m and BUN. The concentration of serum β_2-m in severe group was markedly higher than that in mild group in the first three phases of the illness. The changes of the cencentration of urinary β_2-m is similar to that of serum β_2-m. These results showed that function of kidney tubules and glomeruli were predominantly damaged. We conclude that the simultaneous determination of BUN and β_2-m in scrum. urinc may be the favorable choice to reveal the renal malfunction.
关键词
流行性出血热
微球蛋白
血清
尿
hemorrhagic fever
epidemic
β_2-microglobulin
blood serum
urine
kidney failure
acute
