摘要
为探讨前列腺癌患者抗肿瘤免疫活性，采用间接免疫荧光染色流式细胞计数分析技术检测了35例前列腺癌患者睾丸切除术前后外周血淋巴细胞表型（CD）和NK细胞的变化。结果前列腺癌患者CD细胞、CD4／CD8及NK细胞数均低于正常对照者，CD20细胞增多。睾丸切除术后，前列腺癌无转移的患者CD4细胞、CD4／CD8明显增高，NK细胞数接近正常水平；有转移的患者NK细胞升高较少，与术前比较无统计学差异。认为前列腺癌元转移的患者免疫功能损伤轻，术后恢复快，其预后好于已有转移的晚期患者。
To observe the cellular immunologic status in patients with prostatic carcinoma,the numbers of lymphocyte subset and NK cell were measured with indirect immunofluorecent straining and flow cytometry technique in 30 normal controls and 35 patients with prostatic carcinoma before and after orchiectomy. The results showed that the numbers of CD4 cell and NK cell and the CD4/CD8 ratio in the patients were significantly lower than those in the controls,and the number of CD20 cell was increased. After orchiectomy,the numbers of CD4 cell and NK cell and the CD4/CD8 ratio in 17 patients with no metastasis were higher than those before orchiectomy. Such changes were not found in the patients with cancer metastasis. It is suggested that immune injury is light in patients with early stage carcinoma of prostate. The prognosis of patients with early stage is better than that of patients with late stage.
出处
《临床泌尿外科杂志》
1998年第10期427-429,共3页
Journal of Clinical Urology
