摘要
目的:了解胰腺癌患者乙型肝炎病毒表面抗原(HBsAg)的发生情况,初步论证胰腺癌与乙型肝炎病毒(HBV)感染是否存在相关性,为胰腺癌早期诊断提供证据。方法:采用回顾性研究,分析本院2003年1月～2009年3月胰腺癌、肺癌和糖尿病患者HBsAg阳性率,并与全国普通人群对比。总体与样本率的比较采用Z检验;样本间率的比较采用x^2检验。P<0.05有统计学意义。结果:3 701例患者符合纳入标准,其中胰腺癌组230例,HBsAg阳性率为16.1%;肺癌组1 188例,HBsAg阳性率10.7%;糖尿病组2 283例,HBsAg阳性率为11.6%。肺癌组患者与全国普通人群HBsAg阳性率差异无统计学意义(Z=1.104,P=0.163)。糖尿病组患者与普通人群HBsAg阳性率差异有统计学意义(Z=2.98,P=0.002) 。胰腺癌患者HBsAg阳性率高于肺癌患者,OR=1.60,95% CI:1.077～2.382,X^2 =5.487,P=0.019。胰腺癌患者HBsAg阳性率高于糖尿病患者,OR= 1.46,95% CI:1.004～2.123,X^2=3.965,P=0.046。结论:胰腺癌可能有较高HBsAg阳性率,推测HBV感染与胰腺癌的发生可能存在一定的相关性。
Objective： To analyze the association between hepatitis B virus （HBV） infection and pancreatic cancer. Methods： Retrospective analysis was performed to explore the positive rate of serum hepatitis B virus surface antigen （HBsAg） in patients with pancreatic cancer, lung cancer, diabetes mellitus and general population. Z test was used to compare the rate of HBV infection between the samples and general population. The rates among the samples were compared by Chi-square test. Results： A total of 3,701 registered patients seen in our hospital between January 1st 2003 and March 31st 2009 were collected. There were 230 pancreatic cancer patients with a positive rate of serum HBsAg of 16.1%, 1,188 lung cancer patients with a positive rate of serum HBsAg of 10.7%, and 2,283 patients with diabetes mellitus with a positive rate of serum HBsAg of 11.6%. There was no statistical significance in Z-test results between lung cancer patients and general population （Z=1.104, P=0.163）, but the Z-test results between patients with diabetes mellitus and general population showed a statistical significance （Z=2.98, P=0.002）. The positive rate of HBsAg was higher in pancreatic cancer patients than that in lung cancer patients （OR=1.60, 95% CI： 1.077-2.382, r=5.487, P=-0.019）. Similar results were found between pancreatic cancer patients and diabetic patients （OR=1.46, 95% CI： 1.004-2.123, r=3.965, P=0.046）. Conclusion： The positive rate of HBsAg is high in pancreatic cancer patients. There might be an association between HBV infection and pancreatic cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2009年第24期1388-1390,共3页
Chinese Journal of Clinical Oncology
基金
广东省科技计划项目基金资助(编号:2007B031516014)~~
关键词
乙型肝炎病毒
胰腺肿瘤
相关性
Hepatitis B virus
Pancreatic neoplasm
Association
