摘要
目的了解慢性特发性荨麻疹(CIU)患者血清抗FcεRI抗体水平及其临床意义。方法采用酶联免疫吸附试验法((ELISA)检测50例CIU患者血清抗FcεRI抗体水平,并与20名正常人对照;分析抗FcεRI抗体水平与CIU临床表现的关系。结果CIU患者血清抗FcεRI抗体水平为2.73(0.60～14.45)U/L,正常对照为1.42(0.60～2.30)U/L,两组差异有统计学意义(P<0.05);抗FcεRI抗体水平与CIU病程、瘙痒程度、风团数量和风团大小无相关性(P>0.05)。结论血清抗FcεRI抗体水平增高可作为CIU的辅助诊断指标,但不能用来评价CIU的病情严重程度。
Objective To survey the serum level and clinical value of anti-IgE receptor antibodies in patients with chronic idiopathic urticaria. Methods The serum levels of anti-IgE receptor antibodies in 50 CIU patients and 20 normal controls were detected by ELISA. The correlation of level of anti-IgE receptor antibodies with clinical features of CIU was analyzed. Results The median level of serum anti-IgE receptor antibodies was 2.73（0.60~14.45）U/L in CIU patients,and 1.42 （0.60-2.30）U/L in healthy controls. The serum levels of anti-IgE receptor antibodies in CIU patients were significantly higher than that of the healthy controls （P〈0.05）.The levels of anti-IgE receptor antibodies was not correlated with clinical course,itching,sites and number of wheal in CIU patients （P〉0.05）. Conclusions The increasing serum level of anti- IgE receptor antibodies can be taken as a supplementary indicator for the diagnosis of chronic idiopathic urticaria,but it can not be used for assessment of severity of the disease.
出处
《中国热带医学》
CAS
2010年第1期93-93,128,共2页
China Tropical Medicine
基金
广东省医学科研基金课题(No.A2006142)
关键词
荨麻疹
特发性
慢性
抗FcεRI抗体
Urticaria, idiopathic
Chronic
Anti-IgE receptor antibody
