摘要
目的:通过检测动脉粥样硬化性脑梗死(ACI)患者ALOX5AP基因SG13S114A/T多态性,探讨ALOX5AP基因SG13S114A/T的多态性与ACI的关系,以及SG13S114A等位是否为ACI的易感基因。方法:用聚合酶链反应限制性片段长度多态性分析法,分析412例确诊的ACI和368例同时与其基础疾病相匹配的非ACI者的ALOX5AP基因SG13S114A/T的多态性,比较两组间该基因多态性的差异。结果:ACI组ALOX5AP基因SG13S114AA基因型频率以及A等位基因均高于对照组,但是两组的差异没有统计学意义(P>0.05)。结论:ALOX5AP基因SG13S114A/T的多态性与ACI的发生没有明确的关系,也不能得出该基因的A等位基因为ACI的易感基因的结论。
Objective： To investigate the relationship of the polymorphism of SG13S114A/T in ALOX5AP gene with atherosclerotic cerebral infarction （ACI）. Methods： By polymerase chain reaction and restriction fragment length polymorphism, polymorphism of SG13S114A/T in ALOX5AP gene in 412 cases with ACI and 368 non-ACI controls were analyzed. Results： There were no statistically significant differences in the ALOX5AP gene SG13S114 AA genotype and A allele frequencies between ACI group and control group （P〉0.05）. Conclusion： The results do not support genotype SG13S114 A allele as the risk gene for ACI.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2009年第6期630-633,共4页
Journal of Zhejiang University(Medical Sciences)
基金
浙江省医药卫生科学研究基金资助项目(2008B199)
