摘要
目的:观察昆丹颗粒对代谢综合征(MS)模型大鼠血糖、血脂的影响。方法:Wistar雄性大鼠随机分为空白对照组和造模组,空白对照组灌胃蒸馏水,造模组灌胃高脂高糖高盐乳剂1ml/100g·d-1,连续6周;将MS造模成功的大鼠随机分为模型组、昆丹大剂量组、昆丹中剂量组、昆丹小剂量组、盐酸罗格列酮组;上午以高脂高糖高盐乳剂1ml/100g·d-1灌胃,下午昆丹大、中、小剂量组分别灌胃昆丹颗粒7.5g/kg·d-1、3.75g/kg·d-1和1.87g/kg·d-1,盐酸罗格列酮组灌胃1mg/kg·d-1,空白对照组灌胃蒸馏水。连续给药6周后,检测空腹血糖、血清胰岛素、血脂,计算胰岛素敏感指数。结果:昆丹颗粒大剂量能明显降低MS大鼠的空腹血糖和空腹胰岛素水平,提高胰岛素敏感指数,昆丹颗粒高、中剂量能改善脂代谢紊乱状况,降低TG、TC、LDL-C水平,升高HDL-C水平。结论:昆丹颗粒能有效防治MS的发生发展,机制可能与其提高胰岛素敏感性有关。
Objective：To observe the effects of Kundan granules on blood glucose（BG） and blood lipid in rats with metabolic syndrome. Methods：Male Wistar rats were randomly divided into normal group and model group. Normal group was given distilled water,model group was given high-fat,high-sugar,high-sah emulsion 1 ml/100 g·d^-1 to make metabolic syndrome（MS）. After 6 weeks,the MS model rats were randomly divided into model group,Kundan largedoes group,Kundan medium-does group,Kundan low-does group,rosiglitazone group. Each group was given high-fat, high-sugar,high-sah emulsions 1 ml/100g·d^-1 in the morning,in the afternoon Kundan large,medium and low dose group were given Kundan granules 7.5 g/kg·d^-1,3.75 g/kg·d^-1 and 1.87 g/kg·d^-1（separately 15 times,7.5 times and 3.75 times than that for human-being）,osiglitazone group was given 1 mg/kg·d^-1（7.5 times than that for human-being）, nomal group was given distilled water. The treatment last for 6 weeks to measure the changes in BG,insulin and blood lipid. Insulin sensitive index（ISI） was also calculated. Resuhs：Kundan granules could significantly reduce the BG levels and insulin of MS rats and improve insulin sensitivity;Kundan large and medium does could regulate lipid levels of MS rats,could significantly reduce TG,TC,LDL-C levels and increased HDL-C level. Conclusion： Kundan granules could prevent and treat the occurrence and development of MS effectively,the mechanism is concerned with enhance insulin sensitivity.
出处
《山东中医药大学学报》
2010年第1期75-77,共3页
Journal of Shandong University of Traditional Chinese Medicine
基金
广东省科技厅项目(编号:2009B080701024)
