摘要
目的探讨CT引导经皮经肺微波热凝固治疗周围型肺癌的临床疗效及不良反应。方法在CT引导下,使用单极微波辐射天线经皮经肺穿刺治疗周围型非小细胞肺癌47例(共59个病灶)。微波频率2450MHz,功率40～80W,每点加热10～15分钟。根据肿瘤的直径及形状进行单点固化或者多点多次固化。结果肿瘤微波固化消融治疗后的的即刻CT表现为病灶密度减低或出现气化灶。治疗后2月复查CT显示病灶消失者(CR)5例,病灶缩小>50%者(PR)25例,有效率(CR+PR)为65.96%。随访3～40个月,1年、2年及3年生存率分别为68.1%(32/47),46.8%(22/47),27.7%(13/47)。相关并发症为气胸10例,胸腔积液2例,肺部感染1例。结论CT引导经皮微波热凝固疗法治疗周围型肺癌是有效、微创和安全的新方法。
Objective To evaluate the clinical effect and side-effects of percutaneous microwave coagulation therapy for peripheral lung cancer.Methods CT-guided percutaneous microwave coagulation therapy was performed using a needle mono-pole microwave antenna to treat 47 patients（59 nodules） of peripheral lung cancer.The microwave energy was set at 2450MHz and at 40-80 watt for 10-15min.The treatment was conducted by using single or multiple simultaneously-powered antennas according to the size and shape of the tumor.Results After coagulation,lower density or gasification in the coagulated area was observed in CT.CR was observed in 5 patients and PR（diminution of over 50%） was observed in 25 patients.The overall response rate（CR＋PR） was 65.96%.The 1-,2-,3-years survival rate was 68.1%（32/47）,46.8%（22/47）,27.7%（13/47） respectively.Related complication was observed including pneumothorax in ten cases,pleural effussion in two cases and pulmonary infection in one case.Conclusion CT-guided percutaneous microwave coagulation therapy is an effective,minimally invasive and safe treatment for peripheral lung cancer.
出处
《当代医学》
2009年第35期674-676,共3页
Contemporary Medicine
基金
河南省科技攻关项目(0424410021)
关键词
CT引导
微波热凝固疗法
周围型肺癌
CT-guided
Percutaneous Microwave Coagulation Therapy
Peripheral lung cancer
