摘要
慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）由于日益增长的发病率和痫死率成为全世界主要的健康问题。但是，疾病的确切发病机制还没有被阐明。血管内皮生长因子（Vasculare ndothelial growth factor，VEGF）足血管形成的有效介质．对肺的发育和生理有多重作用。VEGF广泛存在于肺组织，对COPD的两种主要病理生理学表现型（肺气肿和慢性支气管炎）起了很重要的作用，观诵对临床的角度研究VEGF在COPD中的作用。
Chronic obstructive pulmonary disease （COPD） is a major worldwide health problem that has an increasing prevalence and mortality. However, the exact mechanism of initiation and progression of this disease has not been fully elucidated. Vascular endothelial growth factor （VEGF） is a potent mediator of angiogencsis,which has multiple effects in lung development and physiology. VEGF is expressed in several amounts or parts of the lung,while it has been shown that differences in its expression play a significant role in the pathophysiology of two major phenotypes of COPD（emphysema and chronic bronchitis）. The present review is to summarize from a clinical point of view the role of VEGF in COPD.
出处
《国际呼吸杂志》
2010年第1期16-19,共4页
International Journal of Respiration
关键词
血管内皮生长因子
慢性阻塞性肺疾病
肺动脉高压
氧化应激
Vascular endothelial growth factor
Chronic obstructive pulmonary disease
Pulmonary hypertension
Oxidative stress
