摘要
本文用吖啶橙荧光染色法研究了速灭菊酯(Fenvalcrate)对孕鼠骨髓和胎鼠肝血细胞微核生成的影响。结果表明,速灭菊酯剂量为140mg/kg体重时,有微核的嗜多染红细胞出现的频率与对照组相比,有明显增加(p<0.05),剂量为70mg/kg、35mg/kg、17.5mg/kg体重时,与对照组相比,无显著性差异(p>0.05);而胎鼠肝血细胞微核在上述剂量情况下,未发现微核有明显增加(p>0.05)。并发现胎鼠肝血细胞微核自发率略高于孕鼠骨髓微核自发率。
The effects of fenvalerate on micronucleus formation in the bone marrow cells of pregnant mice and in the blood cells of fetal mice live were studied by using acridine orange fluorescent staining. The results showed that the frequencies of micronucleated erythocytes in the bone marrow of pregnant mice markedly increased at the dose of 140 mg of fenvalerate per kg body weight(p o)compared with those of controlled animals (p<0.05). There was no significant difference(p>0.05)between the experimental group and the control group when the doses were 70 mg/kg, 35 mg/kg, and 17.5 mg/kg, respectively. However, there was no marked increase of micronucleated erythocytes in the blood of fetal mice liver at the above doses(p>0.05). We also found that the spontancous frequency of micronucleated erythocytes in fetal liver was higher than those in bone marrow of pregnant mice.
出处
《南京大学学报（自然科学版）》
CAS
CSCD
1990年第1期81-85,共5页
Journal of Nanjing University（Natural Science）
关键词
速灭菊酯
杀虫剂
毒理学
哺乳动物
Acridine orange fluorescent staining
Micronucleus test
Fenvalerate
