摘要
目的：探讨ATP生物荧光法肿瘤体外药敏感性检测（ATP—TCA）在乳腺癌化疗中的应用。方法：应用ATP生物荧光肿瘤体外药物敏感性检测法，检测50例乳腺癌标本对6种常用化疗药物和3种联合化疗方案的敏感性。结果：组织标本的可评估率为92％，乳腺癌细胞对阿霉素（ADM）＋紫杉醇（PTX）联合体外有效率最高为95．3％，其次为ADM＋氟尿嘧啶（5-Fu）90．7％，多西他赛（TXT）72．5％，PTX70．7％，ADM50．0％，甲氨蝶呤（MTX）＋5-Fu 19．5％，MTX9．8％。化疗药物对乳腺癌细胞的杀伤作用具有较强的个体差异。结论：ATP生物荧光肿瘤体外药物敏感性检测法敏感性高、稳定性好、简单、快速、检测结果可靠，可用于临床指导个体化的乳腺癌化疗方案。
Objective：To investigate the application for primary breast cancer chemotherapy by using chemosensitivity （ATP -TCA）. Methods：To detect the chemosensitivity in 50 breast cancer specimens for six signal chemotherapy drugs and three combination chemotherapy drugs by ATP - TCA. Results ： The specimens＇ evaluable rate was 92%. The ADM ＋ PTX demonstrated the strongest sensitivity （95.3%）, ADM ＋ 5 - Fu was 90.7%, TXT 72.5%, PTX 70.7%, ADM 50.0%, MTX ＋ 5 - Fu 19.5%, MTX 9.8%. Breast cancer showed chemosensitivity heterogeneity. Conclusion： ATP- TCA showed sensitivity, tability, simplicity, fast and reliability. The assay can be used to guide breast cancer personal chemotherapy.
出处
《现代肿瘤医学》
CAS
2010年第1期83-85,共3页
Journal of Modern Oncology
关键词
乳腺癌
化疗
敏感性检测
primary breast cancer
chemotherapy
chemosensitivity
