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硼替佐米治疗R-CHOP治疗无效的老年套细胞淋巴瘤患者体会

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摘要 目的提高对老年套细胞淋巴瘤(MCL)临床特点和治疗的认识。方法回顾性分析1例MCL患者的临床特点、治疗经过、结果,结合文献对MCL的病理、免疫表型、基因表达、临床诊治进行复习。结果该例患者以多处淋巴结肿大、腹部隐痛,伴腹泻、便秘、食欲不振为临床特点,CT提示多发淋巴结肿大,淋巴结活检提示:B细胞型恶性淋巴瘤(套细胞型)。免疫组化:LCA(+),CD20(+/-),CD3散在(+),CD19(+),CD43(+),CD79a(+),CD10(-),CD138(-),Ki67(80%+),CyclinD1(+),Bcl-2部分(+),Bcl-6(+)。给予R-CHOP化疗后淋巴结无明显缩小,给予硼替佐米CAP后淋巴结明显缩小。结论MCL对常规治疗不敏感,但使用硼替佐米+CAP后效果显著。
出处 《现代中西医结合杂志》 CAS 2010年第3期334-336,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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参考文献11

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