摘要
目的调查医院铜绿假单胞菌的临床分布、耐药性及其变迁情况,指导临床合理用药。方法采用回顾调查的方法对454株铜绿假单胞菌的标本来源、临床分布及耐药情况进行分析。结果454株中有64.9%来自痰及咽拭子,铜绿假单胞菌感染主要发生在重症监护病房(50.4%);17种抗菌药物2006-2007年耐药率呈上升趋势,2008年细菌耐药上涨势头得到较大程度的控制;其中亚胺培南、哌拉西林/他唑巴坦、阿米卡星、头孢哌酮/舒巴坦对铜绿假单胞菌较为敏感,平均耐药率依次为16.7%、18.5%、21.5%、24.2%;氨苄西林、头孢唑林、头孢曲松、氨苄西林/舒巴坦、呋喃妥因和复方新诺明高度耐药。结论铜绿假单胞菌是医院感染常见条件致病菌之一,耐药严重且有上升趋势,依据药敏结果合理用药十分重要。
OBJECTIVE To investigate clinical distribution,drug resistance and transition of Pseudomonas aeruginosa in the Affiliated Hospital of Ningbo University and guide rational clinical use of drug.METHODS The sample′s origin,clinical distribution and drug resistance of 454 P.aeruginosa isolates were analyzed by retrospectively investigation.RESULTS 64.9% P.aeruginosa isolated from sputum and throat swab and 50.44% of P.aeruginosa infection occurred in ICU.Antibiotic resistance to 17 kinds of antibacterials increased from 2006 to 2007 but were controlled in 2008.Imipenem,piperacillin/tazobactam,amikacin and cefoperazone/sulbactam were sensitive in P.aeruginosa.Antibiotic resistance to ampicillin,cefazolin,ampicillin/sulbactam nitrofurantoin and SMZ-TMP were 16.74%,18.50%,21.59% and 24.23%.CONCLUSIONS P.aeruginosa is one of the most cornmon pathogen in hospital infection.It is important for rational administration according to susceptibility test.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第23期3263-3265,共3页
Chinese Journal of Nosocomiology
关键词
铜绿假单胞菌
抗菌药物
耐药性
Pseudomonas aeruginosa
Antibacterials
Drug resistance
