摘要
目的探讨性激素在食管、贲门癌发病中的作用及临床意义。方法应用放射免疫法对３０例食管、贲门部良性疾病（对照组），４０例食管癌患者（食管癌组），１０例贲门癌患者（贲门癌组）血清睾酮（Ｔ）及雌二醇（Ｅ２）水平进行测定。结果食管癌组Ｔ水平较对照组高（Ｐ＞０．０５），贲门癌组低于对照组（Ｐ＜０．０５）。食管癌组和贲门癌组Ｅ２水平均低于对照组（Ｐ＜０．０１，Ｐ＜０．０５），而术后Ｅ２水平高于术前（Ｐ＜０．０５）。Ｅ２水平与病理分级及癌肿复发有关，Ｔ水平与分级间无差异（Ｐ＞０．０５）。结论性激素在食管癌与贲门癌的发生、发展中起着一定的作用；Ｅ２水平的变化可作为手术指征及预后的一项参考指标，并为性激素治疗食管癌的可能性提供了一定的理论依据。
Objective To study the clinical significance and role of sex hormones in the growth of carcinoma of the esophagus and cardia. Methods Serum testosterone and estradiol levels(STL, SE2L) in thirty cases of benign disease as control, forty cases of esophageal cancer, and ten cases of cardiac cancer were determined with radioimmunoassay methods. Results When compared with the control group, STL in esophageal cancer group was higher (P>0.05),and in cardiac cancer group decreased significantly (P<005), STL in esophageal and cardiac cancer groups were similar(P>0.05), but SE2L were significantly lower (P<0.01,P<0.05). SE2L in two groups after surgery were significantly higher than that before surgery (P<0.05), and were obviously related to pathological classifications and the recurrence of cancer. STL in the patients were not significantly different among the classifications (P>0.05). Conclusion Sex hormone might play a certain role in the development of esophageal and cardiac carcinoma. The changes of SE2L may be regarded as one of the indices of the operative indication and prognosis, and might give a clue to the clinical use of hormone thrapy in the treatment of esophageal carcinoma.
出处
《中国胸心血管外科临床杂志》
CAS
1998年第3期142-143,共2页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
食管癌
贲门癌
性激素
放射免疫测定法
Esophageal carcinoma Cardiac carcinoma Sex hormone Radioimmunoassay method
