摘要
目的：探讨卡托普利和培垛普利对急性心肌梗塞患者血浆血管紧张素Ⅱ、内皮素－１和６－酮－前列腺素Ｆ１α的影响。方法：６３例急性心肌梗塞（ＡＭＩ）患者，发病早期随机分为卡托普利组（ｎ＝２０）、培哚普利组（ｎ＝２２）和对照组（ｎ＝２１），卡托普利和培哚普利连续口服７天。结果：卡托普利组和培哚普利组血浆血管紧张素Ⅱ（ＡｎｇⅡ）显著降低，血浆内皮素－１（ＥＴ－１）在治疗的头３天也明显下降，而血浆６－酮－前列腺素Ｆ１α（６－酮－ＰＧＦ１α）的变化不明显。结论：表明卡托普利和培哚普利能降低ＡＭＩ患者早期血浆ＡｎｇⅡ和ＥＴ－１的水平，减慢６－酮－ＰＧＦ１α的下降。
—玂bjective:To evaluate the effects of captopril and perindopril on the plasma levels of angiotensin Ⅱ (Ang Ⅱ),endothelin1(ET1) and 6keto prostaglandin F1 alpha(6keto PGF1α) in patients with acute myocardial infarction(AMI).Methods:Sixty three patients with AMI were randomized into captopril group (n=20),perindopril group(n=22) and control group (n=21) at the early stage of the disease. Captopril and perindopril were taken orally for seven days. The levels of plasma Ang Ⅱ,ET1 and 6keto PGF1α were determined at the 1st, 2nd,3rd and 7th day.Resu lts:Compared with the control group,plasma Ang Ⅱ levels in the captopril group and perindopril group decreased significantly, and plasma ET1 levels were also reduced on the initial three days,but the changes of plasma 6keto PGF1α levels were not significant.Conclusion:Captopril and perindopril can reduce the levels of plasma Ang Ⅱ and ET1,and slow the decrease of 6keto PGF1α at the early phase of AMI and there are no differences betweem captopril and perindopril.
出处
《滨州医学院学报》
1998年第4期333-335,共3页
Journal of Binzhou Medical University
关键词
急性
心肌梗塞
卡托普利
培哚普利
治疗
captopril
perindopril
acute myocardial infarction
angiotensin Ⅱ
endothelin1
6keto prostaglandin F1 alpha
