期刊文献+

调节性T细胞与过敏性支气管哮喘

原文传递
导出
摘要 这篇综述主要围绕调节性T细胞(regulatory T cells,Treg)在过敏性支气管哮喘(简称哮喘)免疫发病机制中所承担的角色以及以其为靶点的过敏性哮喘的免疫治疗。研究者认为Treg是机体免疫反应程序中关键的调节因素,它能够通过各种机制诱导机体对自身抗原和过敏原产生免疫耐受,从而维持机体免疫系统的稳定。近年来,随着对Treg的研究不断深入,越来越多类型的Treg得以区分。研究发现其中主要是CD4+Treg抑制机体对过敏原的免疫反应,而控制过敏性疾病(过敏性哮喘)的发生和发展。因此,这有力的证实了恢复和诱导过敏性哮喘患者体内Treg的功能是一种有效的潜在的治疗方法。
出处 《中华哮喘杂志(电子版)》 CAS 2009年第5期53-56,共4页 Chinese Journal of Asthma(Electronic Version)
  • 相关文献

参考文献10

  • 1Francis JN,,Till SJ,DurhamSR.Induction of IL-101CD4+CD25+Tcells by grass pollenimmunotherapy[].The Journal of Allergy and Clinical Immunology.2003
  • 2Yazdanbakhsh M,Kremsner PG,Van Ree R.Allergy, parasites, and the hygiene hypothesis[].Science.2002
  • 3Watanabe N,Wang YH,Lee HK,et al.Hassall’s corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus[].Nature.2005
  • 4Karagiannidis C,Akdis M,Holopainen P,et al.Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma[].The Journal of Allergy and Clinical Immunology.2004
  • 5Akdis M,Verhagen J,Taylor A,et al.Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells[].Journal of Experimental Medicine The.2004
  • 6Stock P,Akbari O,Berry G,et al.Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity[].Nature Immunology.2004
  • 7Akira S,Takeda K.Toll-like receptor signaling[].Nature Reviews Immunology.2004
  • 8Mark Larche.Regulatory T Cells in Allergy and Asthma[].Chest.2007
  • 9Heaton T,Rowe J,Turner S, et al.An immunoepidemiological approach to asthma: identification of in vitro T-cell response patterns associated with different wheezing phenotypes inchildren[].The Lancet.2005
  • 10van Oosterhout AJ,Bloksma N.Regulatory T-lymphocytes in asthma[].European Respiratory Journal.2005

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部