期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细胞凋亡调节基因GRIM一19的研究进展 被引量：1

Research progress of apoptosis regulatory gene GRIM-19
原文传递
导出
摘要 GRIM一19是维甲酸／干扰素联合应用诱导细胞凋亡相关基因中的一员，是由Angell等筛选出来的一个新的死亡相关基因，定位于人染色体19p13．1，是线粒体复合体I的组成成分。它可以特异性地与STAT3结合，通过下调STAT3的转录激活活性，抑制其靶基因的表达和细胞生长；此外还可以和蛋白GW112、NOD2等相互作用。国内外已经在原发性肾细胞癌等泌尿系统肿瘤、结直肠癌、甲状腺癌中对GRIM一19的表达进行了研究，提出GRIM-19可能成为一个新的肿瘤抑制基因，并可能成为评价疗效的有用的生物标记物和基因治疗的一个潜在的靶点。 Genes associated with retinoid-interferon mortality-19 （GRIM-19） is one of the apoptosis-related genes induced by retinoid-interferon, is screened by Angell and others. It is located at 19p13.1 of human chromosome as a component of mitochondrial complex I. It can specifically bind to STAT3 to inhibit the expression of target gene and cell growth through down-regulating transcription activity of STAT3. In addition,GRIM-19 can interact with GW112 and NOD2. The studies at home and abroad on the expression of GRIM 19 in renal cell carcinoma and other urologic neoplasms, colorectal cancer and thyroid carcinoma have proposed that GRIM-19 may be a novel tumor suppressor, biological marker for evaluating therapeutic effect and potential target for gene treatment.
作者 周爱民 刘荣玉
机构地区 安徽中医药高等专科学校医疗系 安徽医科大学第一附属医院干部呼吸内科
出处 《国际呼吸杂志》 2009年第24期1513-1517,共5页 International Journal of Respiration
关键词 GRIM一19 细胞凋亡 抑癌基因 GRIM- 19 Apoptosis Tumor suppressor
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献27

  • 1Moore DM, Kalvakolanu DV, Lippman SM, et al. Retinoic acid and interferon in human cancer: mechanistic and clinical studies. Semin Hematol,1994,31(4 Suppl 5):31-37.
  • 2邵月婷,高丽芳,孙连坤,赵丹,计国义,胡嘉弟,李扬,赵雪俭.ATRA联合IFN-α对PC-3细胞株的生长抑制作用以及对GRIM-19和STAT3基因表达的影响[J].肿瘤,2006,26(3):228-231. 被引量：7
  • 3Kimchi A. DAP genes: novel apoptotic genes isolated by a functional approach to gene cloning. Biochim Biophys Acta, 1998,1377 : F13-F33.
  • 4Kalvakolanu DV. The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression. Cytokine Growth Factor Rcv, 2004,15 : 169-194.
  • 5Angell JE, Lindner DJ. Shapiro PS, et al. Identification of GRIM-19, a novel cell death-regulatory gone induced by the interferon-beta and retinoic acid combination, using a genetic approach. J Biol Chem,2000,275:33416-33426.
  • 6周颖,凌斌.GRIM-19的功能及与肿瘤的相关性[J].医学分子生物学杂志,2008,5(3):262-264. 被引量：30
  • 7Huang G, Lu H, Hao A, et al. GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I. Mol Cell Biol, 2004, 24: 8447- 8456.
  • 8Lufei C, Ma J, Huang G, et al. GRIM-19, a death-regulatory gene product, suppresses Star3 activity via functional interaction. EMBO J ,2003,22:1325 -1335.
  • 9Zhang X, Huang Q, Yang Z, et al. GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res,2004,64:2474- 2481.
  • 10Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell, 2003.112:481-490.

二级参考文献111

  • 1胡晓磊,赵允召.克罗恩病的血清学标记物[J].医学研究生学报,2007,20(4):426-429. 被引量：6
  • 2龚龙波,罗学来,刘双又,陶德定,龚建平,胡俊波.GRIM-19及其靶基因产物STAT3与结直肠癌恶性程度的关系[J].癌症,2007,26(7):683-687. 被引量：43
  • 3Angell J E, Lindner D J, Shapiro P S, et al. Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach [J]. J Biol Chem, 2000, 275(43) : 33416 -26.
  • 4Kalvakolanu D V. The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression [ J ]. Cytokine Growth Factor Rev, 2004, 15 (2-3) : 169 - 94.
  • 5Alchanati I, Nallar S C, Sun P, et al. A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM- 19 in human renal cell carcinomas [J]. Oncogene, 2006, 25 (54) : 7138 -47.
  • 6Maximo V, Botelho T, Capela J, et al. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich ( Hurthle cell) tumours of the thyroid[ J]. Br J Cancer, 2005,92 (10) : 1892 -8.
  • 7Liu Y J, Zhuang J, Zhu H Y,et al. Cultured rat cortical astrocytes synthesize melatonin : absence of a diurnal rhythm [ J ]. J Pineal Res, 2007, 43 (3) : 232 - 8.
  • 8Murray J, Zhang B, Taylor S W, et al. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification [ J]. J Biol Chem, 2003, 278 (16) : 13619 -22.
  • 9Fearnley I M, Carroll J, Shannon R J,et al. GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH : ubiquinone oxidoreductase ( complex Ⅰ ) [ J ]. J Biol Chem, 2001, 276(42): 38345-8.
  • 10Burke W M, Jin X, Lin H J, et al. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells[J]. Oncogene, 2001, 20(55): 7925-34.

共引文献74

同被引文献8

引证文献1

二级引证文献3

国际呼吸杂志
2009年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部