摘要
生物制剂在类风湿性关节炎治疗中的应用虽然不到二十年的时间,却取得了较大的效果,并且逐渐成为一种常规的疗法。根据类风湿关节炎发病机制中的不同作用环节,人们开发出了分别针对细胞因子和淋巴细胞的各种各样的生物制剂。本文介绍生物制剂主要作用的对象有肿瘤坏死因子、白细胞介素、淋巴细胞等,他们是类风湿性关节炎各个发病环节中的重要部分。这些生物制剂对于顽固性RA患者有很好的治疗作用,且有较好的安全性。
Although the application of biologic agents treating patients with rheumatoid arthritis only has no longer than 20 years,lots of effect has been obtained. Biologic agents are becoming a normal therapeutic option gradually. According to different biologic targets in the mechanism of rheumatoid arthritis,scientists have researched kinds of biologic agents aiming to cytokines and lymphoid cells,and many other agents are being researched .Biologic agents what are mainly introduced in this text make TNF,IL-,lymphoid cells as their targets,which play important roles in every steps of the mechanism in rheumatoid arthritis. These biologic agents are effective and safe to treat refractory RA.
出处
《现代生物医学进展》
CAS
2009年第21期4172-4174,4171,共4页
Progress in Modern Biomedicine
