摘要
BRDⅡ株风疹减毒活疫苗和基因工程乙肝疫苗同时或分别接种于4～5年前已进行血源乙肝疫苗基础免疫的儿童，结果表明，同时与分别接种的免疫应答类似，临床反应均轻微。2组乙肝疫苗加强免疫后，抗-HBs含量≥mIU／ml者所占的比例和几何均值均有明显提高。
The children immunized with blood-derived HB vaccine 4～5 years ago were randoraly divided into R,H and HR groups and addrinistered .ith live attenuated rubella vaccine prepared with BRD Ⅱ strain,recombinant hepatitis B (HB) vaccine and live attenuated rubella vaccine plus recombinant HB vaccine respectively. In HR group,the 2 kinds of vaccines were injected in right and left arms respectively. No significant difference was found be tween the anti-HBs levels of H and HR groups or the HI antibody levels of R and HR groups. All the adverse reactions of the 3 groups were drild. The proportion of cases with the anti-HBs levels of≥10mIu/ml and GMTs of H and HR groups were significantly increased It indicated that the immune response to HB was not interfered by the simultaneous administration of HB and rubella vaccines.
出处
《中国生物制品学杂志》
CAS
CSCD
1998年第3期178-180,共3页
Chinese Journal of Biologicals
关键词
风疹减毒活疫苗
乙肝疫苗
免疫应答
Live attenuated rubella vaccine
Recombinant hepatitis B vaccine
Immun reponse
