摘要
目的:探讨了肝硬化患者血清ET、TNF-α和endotoxin水平的变化及意义。方法:应用放射免疫分析和分光光度计测定法对61例肝硬化患者(其中30例伴肝硬化腹腔积液,31例无肝硬化腹腔积液)进行了血清ET、TNF-α和内毒素(endotoxin)检测,并与35例正常健康人作比较。结果:肝硬化患者血清ET水平非常显著地低于正常人组(P<0.01),而TNF-α和endotoxin水平非常显著地高于正常人组(P<0.01),肝硬化患者ET水平与TNF-α、endotoxin水平呈明显负相关(r=-0.4785、-0.5012,P<0.01)。结论:检测肝硬化患者血清ET、TNF-α和endotoxin水平的变化对了解病情、观察预后均具有重要的临床价值。
Objective To explore the clinical significance of changes of serum ET,TNF-α and endotoxin levels in patients with liver cirrhosis.Methods Serum ET,TNF-α（with RIA） serum endotoxin（with spectrometry were measured） in 31 patients with cirrhosis of liver complicated with ascites 30 cases without ascites and 35 controls.Results Serum ET levels were significantly lower in the patients with liver cirrhosis as a whole than those in controls（P〈0.01）,while the serum TNF-α,endotoxin levels were significantly higher in the patients with liver cirrhosis than those in controls（P〈0.01）.Serum ET levels showed negative correlation-ship with TNF-α and endotoxin levels（r=-0.4785,-0.5012,P〈0.01）.Conclusion Determination of serum ET,TNF-α and endotoxin levels is of help for assessment of disease process in patients with cirrhosis of liver.
出处
《放射免疫学杂志》
CAS
2009年第6期592-593,共2页
Journal of Radioimmanology
关键词
肝硬化
内皮素
肿瘤坏死因子-Α
内毒素
liver cirrhosis
endothelin（ET）
tumor necrosis factor-α（TNF-α）
endotoxin
