摘要
目的探讨降钙素原(PCT)和高敏C-反应蛋白(SCRP)对新生儿败血症的早期诊断价值。方法用半定量固相免疫层析法和免疫速率浊度法分别测定263例新生儿败血症患儿的血清PCT和SCRP浓度,并与白细胞计数进行比较;测定实验组中214例抗生素治疗有效的患儿血清SCRP浓度,并进行治疗前后的比较。结果PCT、SCRP对诊断新生儿败血症均有较高的灵敏度;PCT的特异度、阳性预测值、阴性预测值、约登指数、准确性都是最高的,SCRP的特异性最低。治疗前后SCRP水平下降差异有统计学意义(P<0.05),能很好地评价疗效。结论PCT和SCRP对新生儿败血症的早期诊断有一定价值。
Objective To explore the diagnostic value of procalcitonin（PCT） and super sensitive C-reactive protein（SCRP） for neonatal sepsis. Methods 263 serum samples of neonatal sepsis were measured for PCT by semiquantitative solid-phase immunochromatography and SCRP by speed immunoturbdimetry assay, and was tested for the comparison with the white blood cell count （WBC） ;214 serum samples of neonatal sepsis,which were cured effectively by antibiotic,were measured for SCRP and the results before and after the treatment were tested and compared. Results Both PCT and SCRP had high sensitivity. PCT had highest specificity, positive predictive value, negative predictive value, youden＇s index and accuracy for diagnosing neonatal sepsis. Conclusion Determination of PCT and SCRP is valuable for the diagnosis of neonatal sepsis.
出处
《检验医学与临床》
CAS
2009年第24期2095-2095,2098,共2页
Laboratory Medicine and Clinic
关键词
降钙素原
高敏C反应蛋白
新生儿败血症
proealcitonin
super sensitive C-reactive protein
neonatal sepsis
