摘要
目的探讨奥曲肽联合奥美拉唑治疗肝硬化上消化道出血的临床疗效。方法将60例患者随机分为观察组和对照组各30例,观察组应用奥曲肽联合奥美拉唑治疗,奥曲肽先予0.1mg静脉推注,然后以25μg/h持续静脉滴注48～72h;奥美拉唑40mg加入生理盐水100mL静脉滴注持续48～72h。对照组使用垂体后叶素,先予20U静脉推注,然后以15U/h微泵维持48～72h;观察各组的止血效果。结果观察组治疗总有效率为93.33%,高于对照组的56.67%,差异具有显著性(P<0.01)。结论奥曲肽联合奥美拉唑是治疗肝硬化上消化道出血的有效措施之一,副反应小,值得临床推广。
Objective To explore the curative effect of octreotide combined with omeprazole in the treatment of upper gastrointestinal hemorrhage in liver cirrhosis. Methods Sixty liver cirrhosis patients with upper gastrointestinal hemorrhage were divided randomLy into observation group（30 eases） and control group（30 cases）. The observation group was treated with octreotide and omeprazole,first intravenous bolus injection of octreotide 0.1mg followed by continuous intravenous infusion of octreotide 25μg/h for 48-72h,and then continuous intravenous infusion of omeprazole 40mg for 48-72h with addition of normal saline 100mL. The control group was treated with pituitrin, first intravenous bolus injection of pituitrin 20U and then intravenous infusion of pituitrin 15U/h with a micro-pump for 48-72h. The hemostatic effect in each group was observed. Results The total effective rate of the observation group（93.33%） was better than that of the control group（56.67%）, with a significant difference between the two groups（P〈0.01 ）. Conclusion The combined use of octreotide and omeprazole is effective in the treatment of upper gastrointestinal hemorrhage in liver cirrhosis,with few side effects,worthy of being recommended in clinical practice.
出处
《中国现代医生》
2009年第34期40-41,共2页
China Modern Doctor
关键词
奥曲肽
奥美拉唑
垂体后叶素
上消化道出血
肝硬化
Octreotide
Omeprazole
Pituitrin
Upper gastrointestinal hemorrhage
Liver cirrhosis
