摘要
目的研究HBeAg阴性慢性乙型肝炎患者的HBV-DNA载量和病理组织学特点及它们之间的关系。方法回顾性收集我院150例HBeAg阴性慢性乙型肝炎患者的临床资料,分析其ALT、HBV-DNA及肝脏病理组织特点,探讨其相关性。结果126例HBV-DNA阳性患者的病毒载量与炎症活动度及纤维化程度分级均呈正相关,年龄与纤维化亦呈正相关。24例HBV-DNA阴性患者仍存在较严重的炎症活动及纤维化。结论HBeAg阴性慢性乙型肝炎患者随病毒载量和年龄增长,其炎症和纤维化加重,血清病毒阴性的慢性乙肝患者肝病仍可能持续进展。
Objective To study the HBV-DNA load and histopathological features of HBeAg-negative chronic hepatitis B and their relationship. Methods We retrospectively collected the clinical data of 150 cases of HBeAg-negative chronic hepatitis B and analyzed the serum ALT,HBV-DNA and liver histopathological features and their relations. Results The viral load was positively correlated with the degree of inflammatory activity and fibrosis grade in 126 cases of HBeAg-negative chronic hepatitis B（P〈0.01 ） and so was age with the fibrosis. There were still more severe inflammatory activity and fibrosis in 24 cases of HBeAg-negative chronic hepatitis B. Conclusion The liver inflammation and fibrosis of HBeAg-negative chronic hepatitis B are aggravated with increasing viral load or age;The liver disease of the case is still likely to continue its progress.
出处
《中国现代医生》
2009年第35期110-111,149,共3页
China Modern Doctor
关键词
肝炎
乙肝E抗原
乙型肝炎
病理学
Hepatitis
Hepatitis B e antigen
Hepatitis B
Histology
