2Blaschuk O,Burdzy K Fritz I B.Purification and characterization of a cell-aggregating factor (clusterin),the major glycoprotein in ram rete testis fluid[J].J Biol Chem 1983,258:7714
3De Silva H V,Harmony JAK,Stuart WD.Apolipoprotein J:Structure and tissue distribution[J].Biochem,1990,29:5380
4Rosenberg M E and Silkensen J.Clusterin:physiologic and pathophysiologic consideratiors.Int J Biochem Cell Biol,1995,27:633
5Humphreys D T,Carver J A,Easterbrook-Smith S B and Wilson M R.Clusterin has chaperone-like activity similar to that of small heat shock proteins.J Biol Chem,1999,274:6875
6Miyake H,Nelson C,Rennie P S,et al.Acquisition of chemoresistant phenotype by overexpression of the antia-poptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models[J].Cancer Res,2000,60:2547
7Miyake H,Chi K N,Gleave M E.Antisense testosterone repressed prostate message-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo[J].Clin Cancer Res,2000,6:1655
8Zellweger T,Miyake H,July L V,et al.Chemosensitization of Human Renal Cell Cancer Using Antisense Oligonucleotides Targeting the Antiapoptotic Gene Clusterin[J].Neoplasia,2001,3:360
9Kirszbaum L,Sharpe J A,Murphy B.Molecular cloning and characterization of the novel human complement-associated protein,SP-40,40:A link between the complement and reproductive system[J].EMBOJ,1989,8:133
10Sintich SM,Steinberg J,KozlowskiJ M.Cytotoxic sensitivity to rumor necrosis factor-α in prostatic cancer cells is regulated by extracellular levels of SGP-2(Clusterin)[J].Prostate,1999,39:87
2PANDEY P, SALEH A, NAKAZAWA A, et al. Negative regula-tion of cytoehrome c~mediated oligomerization of Apaf-1 and ac-tivation of proeaspase-9 by heat shock protein 90 [J], EMBO J,2000,19(16): 4310-4322.
3BLAGOSKLONNY MV, TORETSKY J,BOHEN S,et al. Mutantconformation of p53 translated in vitro or in vivo requires func-tional HSP90[J]. Proe Natl Acad Sci USA, 1996, 93(16): 8379-8383.
4ZHAO C, WANG EH. Heat shock protein 90 suppresses tu-momecrosis factora induced apoptosis by preventing the cleavageof bid in NIH3T3 fibroblasts[J]. Cell Signal, 2004, 16(3): 313-321.
5REDONDO M, TELLEZ T, ROLDAN MJ. The role of clusterin(CLU) in malignant transformation and drug resistance in breastcarcinomas[J]. Cancer Res, 2009, 105: 21-43.
6ROSENBERG ME, SILKENSEN J. Clusterin: physiologic andpathophysiologic considerations [J]. Int J Biochem Cell Biol,1995,27(7): 633-645.
7LI Y, GAO S, JING H M, et al. Correlation of chemical acute toxicity between the nematode and the rodent [ J ]. Toxicology Research, 2013,2 : 403 -412.
8Harris T W, CHEN N, Cunningham F,et al. WormBase : a multi- species resource for nematode biology and genomics[ J]. Nucleic Acids Res ,2004,32 ( Database issue) :411- 417.
9Link C D. Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans [ J ]. Proc Natl Acad Sci USA, 1995,92(20) :9368-9372.
10Drake J, Link C D, Butterfield D A. Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid β-peptide ( 1-42 ) in a transgenic Caenorhabditis elegans model [ J ]. Neurobiology of Aging, 2003,24 : 415- 420.