摘要
目的观察奥扎格雷钠(丹奥)对非ST段抬高心肌梗死(NSTEMI)患者血液流变学指标、血浆内皮素和一氧化氮的影响,探讨其治疗价值。方法81例非ST段抬高的急性心肌梗死患者随机分为对照组和观察组,对照组使用单硝酸异山梨酯、低分子肝素、辛伐他汀,观察组在对照组治疗的基础上加用奥扎格雷钠,观察其临床疗效和血液流变学指标及血浆内皮素(endothelin,ET)和一氧化氮(nitrogen monoxidum,NO)的变化。结果观察组疗效优于对照组(P<0.05)。治疗后观察组与对照组ET水平均较治疗前明显降低(P<0.05),NO水平均较治疗前升高(P<0.05);且治疗后观察组ET、NO水平均较对照组改变明显(P<0.05)。治疗后观察组各项血液流变学指标均低于治疗前(P<0.05);对照组仅全血比黏度高切、血小板黏附率、纤维蛋白原低于治疗前(P<0.05);治疗后观察组各项指标均低于对照组(P<0.05)。结论奥扎格雷钠能有效改善非ST段抬高急性心肌梗死患者的血液流变学指标和ET、NO水平,在常规治疗的基础上加用奥扎格雷钠能起到更好的治疗效果。
Objective To investigate the effect of sodium ozagrel injection on hemorheology, endothelin （ET） and nitrogen monoxidum （NO） of patients with non-ST segment elevation myocardial infarction （NSEMI）. Methods A total of 81 NSEMI patients were divided randomly into two groups： control group and experimental group. Isosorbide mononitrate, low molecular heparin and simvastatin were administered in the control group while sodium ozagrel was added to the experimental group apart from the above-mentioned drugs. The clinical effect of sodium ozagrel was observed. The changes in the indexes of hemorheology, ET and NO were analyzed. Results The clinical effect was significantly better in the experimental group than in the control group （P〈0.05）. The level of ET was obviously lower after treatment than that in the experimental group and the control group before treatment （P〈0.05）. The level of NO was obviously higher after treatment than that in the experimental group and the control group before treatment （P〈0.05）. The changes of ET and NO in the experimental group post-treatment were more significant than those in the control group after-treatment （P〈0.05）. The level of hemorheology index after treatment was lower than that before treatment in the experimental group （P〈 0.05）. High-shear rate of whole blood viscosity, platelet adherence rate, and fibrin as hemorheology indexes were lower after-treatment than those pretherapy in the control group （P〈0.05）. Conclusion Sodium ozagrel injection could affect hemorheology,ET and NO of patients with non-ST segment elevation myocardial infarction. Thefore, the therapeutic efficacy can be better if sodium ozagrel is added to the conventional therapy.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2009年第6期720-723,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
河南省科技厅科技发展计划资助项目(No.0424410044)~~
关键词
奥扎格雷钠
血液流变学
内皮素
一氧化氮
非ST段抬高心肌梗死
sodium ozagrel injection
hemorheology
nitrogen monoxidum
non-ST segment elevation myocardial infarction
