摘要
细胞凋亡一般分为细胞外途径和细胞内途径。细胞内途径是在线粒体水平启动的细胞死亡,细胞外途径是通过位于细胞膜的死亡受体传导的细胞死亡信号而引起的细胞凋亡途径。肿瘤坏死因子相关的凋亡诱导配体(TRAIL)信号传导通路是指以TRAIL为配体,通过与死亡受体(DR4,DR5)结合而启动凋亡信号,最终诱导细胞凋亡。本文将对TRAIL信号传导通路与肿瘤治疗进行综述。
There exist two major apoptotic signaling pathways： the intrinsic mitochondria-mediated pathway, and the extrinsic death receptor-induced pathway. TNF-related apoptosis-inducing ligand （TRAIL）, which is the ligand for death receptor 4 （DR4） and death receptor 5 （DR5） and induces apoptosis by ligation with DR4 or DR5. We review the characteristic of TRAIL and its receptors, the mechanism of apoptosis induced by TRAIL, the distribution of death receptors in cancer, and applications and prospects of TRAIL signaling pathway in the treatment of cancer.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第12期1336-1342,共7页
Acta Pharmaceutica Sinica
