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p27蛋白在卵巢癌组织中的表达变化及意义 被引量:1

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摘要 目的观察p27蛋白在卵巢癌组织中的表达,探讨其临床意义。方法采用免疫组化SP法检测30份正常卵巢癌组织、30份良性卵巢肿瘤及110份恶性卵巢肿瘤组织中的p27蛋白。结果p27在正常卵巢组织、良性卵巢瘤和卵巢癌组织中的阳性率分别为96.7%、83.3%、35.5%,强阳性率分别为43.3%、33.3%、7.3%,P均<0.05。p27蛋白表达与卵巢癌临床分期、组织分化及淋巴结转移有关(P<0.05),与组织学类型、腹水量无关(P>0.05)。结论p27蛋白在卵巢癌组织中表达下降,对判断卵巢癌的恶性程度及预测预后有一定价值。
出处 《山东医药》 CAS 北大核心 2009年第47期63-64,共2页 Shandong Medical Journal
基金 广西科技厅自然基金资助项目(桂科自0223057)
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