摘要
目的:建立肠癌肝阴虚证量化辨证标准。方法:在对311例肠癌患者进行临床流行病学调查的基础上,组织专家组对其进行辨证,根据各相关中医症状在肝阴虚证组和非肝阴虚证组中出现状况的差异对这些症状进行赋分;应用ROC曲线的方法选择最佳诊断阈值从而建立量化辨证标准;以专家组统一辨证作为"金标准"对建立的量化标准进行回顾性检验。结果:盗汗、肢体麻木、头晕、耳鸣、目涩、烦躁、面部烘热、舌红、脉细为肠癌肝阴虚证的相关中医症状,分别赋分为6、13、11、7、20、8、5、4、2分;量化辨证标准为≥17分;回顾性检验的敏感度、特异度、准确度均在90%以上,阳性似然比10.28。结论:建立的量化标准的特点是:①较符合肠癌的临床特点;②符合中医辨证的临床实际;③数理统计方法的运用比较合理。
Objective： To set a quantified standard on Ganyin -Deficiency syndrome of large intestine cancer. Methods ： Identify Ganyin - Deficiency syndrome according to opinion of experts in the light of clinical epidemiological investigation on 311 patients suffering from Large intestine cancer and evaluate its correlative symptoms on the basis of difference of their appearance between Ganyin - Deficiency syndrome ans no - Ganyin - Deficiency syndrome, and set its quantified diagnosis standard and test it retrospectively. Results ： night sweat, limb numbness, dizziness, tinnitus , eyes dry, fidget, face hot, red tongue and thin pulse are its relative symotoms which are endowed with 6,13,11,7,20,8,5,4,2 points respectively;the diagnosis standard of Ganyin -Deficiency syndrome of large intestine cancer is 17 points;the Sen, Spe and ACC of retrospective examination are all over 90% and its ＋ LR is 10.28. Conclusions ：the quantified standard on Ganyin - Deficiency syndrome of large intestine cancer has its characteristics ： （1）Accordance with clinical characteristic of large intestine cancer; （2）Accordance with characteristic of TCM syndrome diagnosis;（3）Rigorous statistical methods.
出处
《中华中医药学刊》
CAS
2009年第12期2580-2582,共3页
Chinese Archives of Traditional Chinese Medicine
基金
上海市卫生局科研基金资助项目(044039)
上海市中医肿瘤特色专科
上海市中医肿瘤优势专科建设资助项目
关键词
肠癌
肝阴虚证
量化标准
临床流行病学
large intestine cancer
ganyin-deficiency syndrome
quantified standard
clinical epidemiology
