摘要
目的:研究超声波频率、强度、作用时间、传导耦合剂对氢溴酸高乌甲素经皮吸收的影响。方法:制备氢溴酸高乌甲素凝胶,测定在不同超声波作用频率、时间和强度下,以及不同耦合剂对透皮吸收速率和累积透皮吸收量的影响。结果:随着超声频率的增大,单位面积的累积透过量、稳态透皮速率都增大;导入强度可以在一定程度上影响药物的透皮吸收;超声波导入时间在一定范围内,可以促进药物的透皮吸收。结论:超声波导入效果与其频率、强度、作用时间等参数有关,可以通过改变参数来促进氢溴酸高乌甲素的透皮吸收。
OBJECTIVE To study the ultrasound,intensity,effective time, and different couplant on drug transdermal delivery in vitro. METHODS Preparated with lappaconitine hydrobromide gels, the influence of different ultrasound,intensity, effective time. and different couplants on the transdermal parameters per unit cumulative absorbing quantity （Q8hr） and steady sate penelration rate （Js） were determined. RESULTS The transdermal per unit （Q8hr ） and （Js） were increased with the ultrasound frequencies, CLUSION can change ultrasound intensity and eff ective time could affect the action in some degrees on drugs transdermal delivery. CONSION Sonophoresis s, including ultrasound, intensity, effective time, affected its action on drugs transdermal delivery. We the parametres to accelerate the transdermal absorption of lappaconitine hydrobromide.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第24期2091-2094,共4页
Chinese Journal of Hospital Pharmacy
关键词
超声波
透皮吸收
氡溴酸高乌甲素
ultrasound
transdermal delivery
lappaconitine hydrobromide
