摘要
【目的】研究西咪替丁对轮状病毒(rotavirus,RV)肠炎患儿血清细胞因子IL-2、IFN-γ、TNF-α的影响及其治疗效果。【方法】RV肠炎患儿75例,随机分为治疗组(n=38)和对照组(n=37)。两组在补液、调整饮食、微生态疗法等常规治疗的基础上,治疗组用西咪替丁10 mg/(kg.d)静滴;对照组应用抗病毒药物治疗。采用ELISA双抗体夹心法检测治疗前后血清IL-2I、FN-γ、TNF-α水平。观察大便次数、性状及全身症状的恢复时间及3项指标的变化。【结果】治疗组、对照组显效率(治疗3 d)分别为94.7%和64.7%,总治愈率分别为97.4%和78.4%,差异有显著性(P<0.05)。两组治疗后血清IL-2较治疗前明显升高(P<0.01),TNF-α较治疗前明显降低(P<0.01)。治疗组IFN-γ较治疗前明显降低(P<0.01),对照组IFN-γ治疗前后无明显变化(P>0.05)。治疗组均较对照组变化明显(P<0.01)。【结论】IL-2I、FN-γ、TNF-α参与RV肠炎的炎症反应。西咪替丁治疗RV肠炎有效,与调节机体炎症免疫反应有关。
[Objective] To observe the effect of Cimetidine in the treatment for rotavirus enteritis and the changes of serum cytokines （IL-2,IFN-γ,TNF-α）. [Methods] In the 75 infants with rotavirus enteritis,37 cases were treated with antiviral drug in addition to fluid therapy, accommodation of food and drink and microecological preparations （control group） ,the other 38 cases with cimetidine [10 mg/（kg , d） ivdrip] in addition to fluid therapy,accommodation of food and drink and micro ecological preparations （observation group）. Serum IL-2, IFN-γ and TNF-α levels were measured by the method of double antibodies ELISA. The numbers and traits of stools and the patient＇s general conditions were recorded,at the same time,serum IL-2 ,IFN-γ and TNF-a levels were detected. [Results] The total effective rate and markedly effective rate of observation group were significantly difference than those of control group（ χ2=8. 67,4.73, P〈0.05 ）. After treatment, serum IL-2 levels were significantly increased and TNF-α levels were significantly decreased in two groups （P〈0.01 ）. Observation group IFN-γ were significantly decreased（P〈0.01）. Control group IFN-γ had no significantly difference（P〉0.05）. The cytokines of observation group were significantly changed than those of control group（P〈0.01）. [Conclusions] IL-2,IFN-γ and TNF-α are involved in the pathogenesis of RV enteritis. The efficacy of cimetidine in the treatment of RV enteritis is related to readjusting the inflammatory immune response.
出处
《中国儿童保健杂志》
CAS
2009年第6期659-660,共2页
Chinese Journal of Child Health Care
