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Nrf2在肝细胞中作用的研究进展 被引量:4

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摘要 转录因子NF-E2相关因子2(Nrf2)是细胞防御过氧化应激的重要调节因子,可以上调一系列解毒酶和抗氧化蛋白的基因表达,从而减轻活性氧(ROS)和亲电子物质介导的细胞损害。许多研究发现,Nrf2有保护肝细胞免受毒物损害、抑制化学致癌、减轻肝脏炎症和纤维化、抑制脂质沉积等作用。现就Nrf2在肝细胞中的作用进行综述。
出处 《国际消化病杂志》 CAS 2009年第6期381-383,423,共4页 International Journal of Digestive Diseases
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