摘要
为评价链激酶溶栓治疗急性心肌梗死（ＡＭＩ）对左心室功能的影响，应用二维超声心动图对２６例接受链激酶溶栓治疗的ＡＭＩ患者和２７例未溶栓的ＡＭＩ患者，分别在急性期及６个月后随访时测量并计算左心室容积（ＥＤＶ和ＥＳＶ），射血分数（ＥＦ）以及室壁运动指数（ＧＷＭＩ和ＲＷＭＩ）。以上各项指标在急性期时比较各组无显著性差异；在随访期再通组ＥＦ值明显高于未通组和未溶栓组，再通组左室容量减小。急性期各组心功能无差异，随访时再通组心功能较未通组显著改善。提示：链激酶溶栓能明显减轻ＡＭＩ患者的左心室扩张。
The aim of this study was to assess the effects of streptokinase thrombolytic reperfusion on left ventricular size and function evaluated by twodimensional echocardiography. Twentysix patients with first acute myocardial infarction(AMI) receiving thrombolytic therapy were divided into reperfusion group and nonreperfusion group acording to the clinical characteristics. Twentyseven cases with AMI not receiving thrombolytic therapy was unthrombolysis group. Left ventricular enddiastolic volume(EDV), endsystolic volume(ESV), and ejection fraction(EF) were determined by Sipson biplane formula. Global and regional wall motion score indices (GWMI and RWMI) were also analyzed. There was no significant difference in all the parameters among those groups during AMI period. During 6 month′s followup, all parameters, except EF, were higher in the nonreperfusion group and the unthrombolysis group than those in the reperfusion group(P<0.01 for all). EF in the reperfusion group was significantly improved during followup and was higher than that in the nonreperfusion(P<0.01). The result suggest that reperfusion with thrombolysis after AMI can prevent left ventricular dilatation. It can also improve heart function and prognosis.
关键词
链激酶
溶栓疗法
左心室功能
心肌梗塞
治疗
myocardial infarction streptokinase thrombolytic therapy ventricular function, left
