摘要
目的：观察Ｓ┐腺苷┐Ｌ┐蛋氨酸（思美泰）治疗不中断肠外营养情况下ＴＰＮ所致胆汁淤积的疗效。方法：对８例应用ＴＰＮ＞４周、发生胆汁淤积的病人，给予ＴＰＮ支持同时应用思美泰５００ｍｇ２／ｄ，静滴，连续应用４周。结果：治疗后血浆总胆红素、γ┐谷氨酰转肽酶、碱性磷酸酶、谷丙转氨酶、谷草转氨酶明显降低（Ｐ＜０．０５）。肝脏穿刺活检示肝细胞内胆汁淤积及门管区炎症减轻，胆小管内胆栓溶解。结论：静脉给予Ｓ┐腺苷┐Ｌ┐蛋氨酸具有明显的治疗ＴＰＮ所致胆汁淤积的作用。
Objectives:To observe the effects of S adenosyl L methionine on cholestasis induced by parenteral nutrition. Methods:When 8 patients had been diagnosed with cholestasis,their total parenteral nutrition had been used for more than 4 weeks.Each patient was given S adenosyl L methionine,500 mg,2 times perday,by intravenous route continously for 4 weeks. Results:Plasma concentrations of total bilirubin,γ GT,AKP,GPT and GOT were obviously reduced after the use of the drug( P <0.05).Percutanous transhepatic biopsy showed that intraceller cholestasis and inflammetion around portal areas decreased,cholochrome embolus in bile ductules had dissolved. Conclusions:Given S adenosyl L methionine by intravenous route has an obvious role in treating cholestasis from total parenteral nutrition.
出处
《肠外与肠内营养》
CAS
1998年第4期195-198,共4页
Parenteral & Enteral Nutrition
关键词
全肠外营养
腺苷蛋氨酸
胆汁淤积
Total parenteral nutrition S adenosyl L methionine Cholestasis
