摘要
目的应用动态血压监测苯那普利降压效果和对血管系统及醛固醇和内皮素水平的影响。方法３６例病人以普那普利１０～２０ｍｇ治疗前后分别进行动态血压监测，放免测试血浆肾素活性、血管紧张素、醛固醇和内皮素水平。结果治疗组偶测血压和动态血压显著降低，降压谷峰比值为７１％。但肾素活性稍为增加（无统计学意义）。结论苯那普利除降压外。
Aim\ to appraise the antihypertensive effect of benazepril in patients with mild to moderate hypertension and to inviestigate the changement of renin activity(PRA), angiotensinⅡ(AngⅡ), endothelin(ET) and aldosterone in plasma. Methods\ Thirty six hypertensive patients were given benazepril 10～20 mg once daily. ABPM were recorded before and after 4 weeks of benazepril treatment. The PRA,AngⅡ,Ald and the ET were measured with radioimmunoassay(RIA) before and after therapy. \ Results\ The casual blood pressure(CBP) in patients decreased obviously after 4 weeks treatment. AngⅡ,ET and aldosterone decreased( P <0.05),although the PRA was non significantly increased. \ Conclusion\ Benazepril decreased the blood pressure and reduced the blood Ang,ET and aldosterone.
出处
《高血压杂志》
CSCD
1998年第3期196-198,共3页
Chinese Journal of Hypertension
关键词
高血压
苯那普利
肾素血管紧张素系统
内皮素
醛固酮
hypertension
\ benazepril
\ ABPM
\ renin angiotensin system
endothelin
aldosterone
