摘要
以Ｎ－甲基－Ｎ’－硝基－Ｎ－亚硝基胍（ＭＮＮＧ）诱发大鼠胃癌的方法观察胃炎消防治胃癌的作用。结果表明，胃炎消组肿瘤发生率（７／２０，３５％）明显低于空白对照组（１３／２２，５９．１％），且肿瘤只限于胃腺癌的早期癌，而空白组除出现胃腺癌的早期癌外，还出现了胃腺癌的晚期癌，并兼有十二指肠癌、胃平滑肌肉瘤和腹腔肿瘤。对两组胃和十二指肠癌变过程组织病理学进行计量分析，空白组平均分值４．１，胃炎消组平均分值２．７（Ｐ＜０．０５）。
Upon observing the effect of Chinese Patent drug Weiyanxiao (WYX) to prevent and cure rat's gastric carcinoma induced by MNNG, the results of this study showed the incidence of gastric carcinoma in WYX group was significantly lower(7/20,35%) than that in control(13/22,59.1%),and the tumorigenesis was only at the early stage of gastro_adenocarcinoma compared with the control not only at the early stage of gastro_adenocarcinoma but also at the late stage of it, carcinoma of duodenum, gastro_leiomyosarcoma and celiac tumor. The quantitative analysis in histopathology of cancerating courses of gastro_adenocarcinoma and duodenum carcinoma in two groups, the mean score was 4.1 in control and 2.7 in WYX group (P<0.05).It suggested that Chinese patent drug WYX may delay the cancerating course induced by MNNG.
出处
《中药新药与临床药理》
CAS
CSCD
1998年第3期155-157,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
