摘要
目的探讨非胰岛素依赖型糖尿病（ＮＩＤＤＭ）病人血管假血友病因子（ｖＷＦ）的改变及格列吡嗪（Ｇｌｉｐｉｚｉｄｅ）对治疗的影响。方法对２３例未出现并发症的ＮＩＤＤＭ病人血浆ｖＷＦ进行了测定，并用Ｇｌｉｐｉｚｉｄｅ治疗。结果ＮＩＤＤＭ病人血浆ｖＷＦ水平显著高于对照组（１．７９±０．３７ｖｓ１．２９±０．１６）；Ｇｌｉｐｉｚｉｄｅ治疗２个月后血浆ｖＷＦ水平显著下降（１．７９±０．３７ｖｓ１．５６±０．２９），但仍高于对照组（１．５６±０．２９ｖｓ１．２９±０．１６）。结论ＮＩＤＤＭ病人在出现并发症之前，就已有血管内皮损伤；Ｇｌｉｐｉｚｉｄｅ治疗可减轻血管内皮细胞损伤的程度。
Objectice To investigate the changes of plasma vWF( von willebrand factor) in NIDDM patients without diabetic complications.Mothod The levels of plasma vWF were measured,in 23 patients of NIDDM and 20 normals as control,and 23 patients were on Glipizide therapy.Result The plasma vWF levels in NIDDM patients were higher significantly than those in control.After 2 months Glipizide therapy,the levels of plasma vWF had a great decrease,compared with before,but was also higher than those in control.Conclusion The injury or aberant function of the vascular endothelium exists before diabetic complications,which can increase the incidence of vascular disease in NIDDM.Glipizide therapy can prevent the diabetic vascular disease to a certain degree.
出处
《潍坊医学院学报》
1998年第3期184-185,共2页
Acta Academiae Medicinae Weifang
关键词
糖尿病
格列吡嗪
NIDDM
VWF
测定
non-insulin dependent diabetic mellitus(NIDDM)
von willebrand factor(vWF)
Glipizide
