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血浆制品中人细小病毒B19的灭活/去除研究进展 被引量:2

The progress in research of the inactivation/removal of human parvovirus B19 in plasma-derived products
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摘要 存在于血浆制品中的人细小病毒B19(human parvovirusB19,B19)是传播B19的潜在危险,尤其是B19可经污染的血浆制品的输注而在易感人群中传播。据认为,B19对普通的理化灭活方法有较强的抵抗力。然而,各项研究显示,B19对加热和低pH处理较敏感。因此,可以选择合适的方法来灭活B19。 The presence of human parvovirus B19 (B19) in plasma-derived products indicates a potential risk of B19 transmission, and especially, B19 may be transmitted by transfusion of the contaminated plasma and plasma-derived products in susceptible individuals. It is believed that B19 is more resistant to common physieochemical inactivation methods. However, the various studies show that B19 is more sensitive to heat and low pH treatment. So suitable methods may be selected to inactivate B19.
出处 《国际生物制品学杂志》 CAS 2009年第6期320-323,共4页 International Journal of Biologicals
关键词 细小病毒B19 生物制品 病毒灭活 Parvovirus B19, human Biological products Virus inactivation
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参考文献22

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同被引文献9

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  • 7赵雄,尹惠琼,章金刚.纤维蛋白原制品病毒灭活方法研究进展[J].中国输血杂志,2008,21(2):141-144. 被引量:13
  • 8杨立宏,岳广智,徐宏山,刘欣玉,王志伟,董关木,贾丽丽.终端干热法灭活凝血因子类制品中细小病毒的工艺验证[J].中国生物制品学杂志,2010,23(9):1018-1020. 被引量:7
  • 9张延莹,李宏昊,姜燕.血液制品灭活及去除病毒工艺[J].中国生化药物杂志,2002,23(4):207-209. 被引量:13

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