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Fe_3O_4纳米颗粒表面的修饰和表征 被引量：2

Surface Modification and Characterization of Fe_3O_4 Nanoparticles
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摘要 采用吐温-80和司盘-80修饰亲脂性磁性Fe3O4纳米颗粒,使亲水基团OH-暴露在外层,再通过N-[(3-三甲氧基甲硅烷基)丙基]乙二胺三乙酸三钠,使纳米颗粒的外表面带COO-基团,该基团经EDC活化后可使纳米颗粒与牛血清白蛋白交联,并经红外光谱检测予以证实。 Lipophilic magnetic Fe3O4 nanoparticles were surface modified with Tween-80 and Span-80 so that the hydrophilic group OH- could expose to the outer layer. Then group COO connected to the nanoparticles by N- [（3- trimethoxysilyl） propyl] ethylenediamine triacetic acid trisodium salt was activated with EDC to crosslink of bovine serum albumin （BSA）. The Fourier transformed infrared spectrum confirmed that magnetic Fe304 nanoparticles were conjugated with BSA.
作者 张士新 马明 李芳秋
机构地区 南京师范大学生命科学学院 南京军区南京总医院解放军临床检验医学研究所 东南大学生物科学与医学工程学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2009年第12期915-918,共4页 Chinese Journal of Pharmaceuticals
基金 国家自然科学基金资助项目(30670599) 国家973计划(2006CB705707) 南京军区医学科学技术"十一五"研究计划重点项目(06Z43)
关键词 纳米FE3O4 表面修饰 牛血清白蛋白 Fe3O4 nanoparticle surface modification bovine serum albumin
分类号 R944.9 [医药卫生—药剂学]
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参考文献11

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共引文献17

同被引文献15

  • 1李芳秋,杨爱龙,缪家文,张春华,吴波,张新华.人精子蛋白17单克隆抗体的制备及特性鉴定[J].细胞与分子免疫学杂志,2006,22(5):638-640. 被引量：13
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引证文献2

二级引证文献4

中国医药工业杂志
2009年 第12期

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