摘要
目的:探讨子宫颈上皮内瘤变及子宫颈鳞癌中增殖细胞核抗原(Ki267)表达及其意义。方法:应用免疫组化S2P法检测子宫颈鳞癌15例、子宫颈上皮内瘤变87例、正常子宫颈组织20例中Ki-67表达水平并进行分析。结果:Ki267在子宫颈上皮内瘤变和子宫颈鳞癌组中阳性表达率明显高于子宫颈正常组。从正常子宫颈组织、子宫颈上皮内瘤变到子宫颈鳞癌,Ki267的表达强度逐步增强,两者呈正相关。结论:Ki-67参与了子宫颈上皮内瘤变、子宫颈鳞癌的发生,Ki-67检测可提高子宫颈鳞癌的早期诊断率。
Objective： To explore the expression and significance of Ki -67 in cervical intraepithelial neoplasia （CIN） and cervical squamous cancer. Methods： The expression levels of Ki -67 in 15 cases with cervical squamous cancer, 87 cases with CIN and 20 cases with normal cervical epithelia were detected by immunohistochemistry. Results ： The positive rates of Ki - 67 in CIN and cervical squamous cancer were significantly higher than that in normal cervical epithelia. The expression level of Ki - 67 increased from normal cervical epithelia, CIN to cervical squamous cancer, there was a positive correlation. Conclusion ： Ki - 67 may involve in genesis of CIN and cervical squamous cancer, detection of Ki- 67may increase the early diagnostic rate of cervical squamous cancer.
出处
《中国妇幼保健》
CAS
北大核心
2009年第35期5071-5072,共2页
Maternal and Child Health Care of China
关键词
KI-67
子宫颈上皮内瘤变
子宫颈鳞癌
免疫组化
Ki -67
Cervical intraepithelial neoplasia
Cervical squamous cancer
Immunohistochemistry
