摘要
目的分析有不良孕产史夫妇的异常核型发生率、形成原因及其染色体分析的临床价值。方法对328对有不良孕产吏夫妇的外周血染色体进行G显带染色，分析核型。结果检出异常染色体核型55例，检出率为8．38％（55／656）。异常核型中，多态性变异41例，占异常总数的74．55％（41／55）；其它异常共有14例，占25．45％（14／55）。多态性变异包括D，G组短臂增长23例，次缢痕增长1例，大Y染色体13例，9号染色体臂间倒位2例，其它非多态性异常包括易位、倒住等共14例。结论染色体多态性影响生育，应引起重视。对于不明原因的反复流产夫妇，染色体分析必须作为常规的检测方法。
Objective To analyze the incidence and reasons of abnormal karyotypes and clinical value of chromosome analysis in couples with unhealthy gravidity history. Methods Chromosome analysiswas performed on 328 couples with unhealthy gravidity history. Results 55 cases of abnormal karyotypes were detected 8.38% （55/656）. Among these 55 cases, 41 cases（74. 55%） were karyotype variations,with the remaining 14 cases （25.45%） being non-polymorphic chromosomal abnormalities. Karyotype variations included 23 cases of satellite increases in the D/G group, 1 case of secondary constriction increases, 13 cases of big Y chromosome and 2 cases of pericentric inversion of chromosome 9. Conclusion Chromosome polymorphisms should be think highly for its clinical effect on procreation. Chromosomal analysis should be carried out routinely in every couple with unexplained failure of reproduction.
出处
《现代检验医学杂志》
CAS
2009年第6期125-127,共3页
Journal of Modern Laboratory Medicine
关键词
反复流产
核型
染色体异常
recurrent spontaneous abortion
karyotype
chromosome aberrations
