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血管生成素-2在卵巢子宫内膜异位症中的表达及其临床意义 被引量：2

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摘要 目的 探讨血管生成素-2（Ang-2）与血管生成的关系，及其在卵巢子宫内膜异位症（EMs）中表达的意义。方法应用Elivision Tmplus免疫组化方法检测50例卵巢EMs患者异位和在位内膜组织中Ang-2、微血管密度（MVD）的表达，并以30例正常子宫内膜为对照，应用计算机图像分析系统对结果进行体视学分析。结果EMs异位内膜、EMs在位内膜和正常子宫内膜中Ang-2的表达水平分别为（0．28±0．13）、（0．16±0．05）及（0．13±0．04），MVD分别为（41．58±14．72）、（31．30-4-19．89）及（20．70±16．17），差异均有统计学意义（F=6．92、17．64，P均〈0．01）；EMs组在位内膜和对照组分泌期Ang-2的表达[（0．19±0．04）、（0．14±0．11）]高于增生期[（0．15±0．05）、（0．11±0．22），t=2．859，2．522，P均〈0．05]；Ang-2、MVD在EMs异位和在位内膜中表达呈明显正相关（r=0．945，P〈0．01；r=0．648，P〈0．05），而在对照组中 无明显相关性。结论Ang-2可能与EMs的发生、发展密切相关。
作者 张晓玲 王爽 朱清仙
机构地区 江西省妇幼保健院妇科 南昌大学
出处 《中国综合临床》 2009年第12期1311-1313,共3页 Clinical Medicine of China
关键词 子宫内膜异位症 血管生成素-2 微血管密度 血管生成
分类号 R711.71 [医药卫生—妇产科学] R541 [医药卫生—心血管疾病]
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参考文献7

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共引文献2

同被引文献29

  • 1张真真,张声,林建银,黄培生,陈余鹏.促血管生成素及其受体的异常表达与胃癌血管生成的关系[J].中华肿瘤杂志,2006,28(4):280-284. 被引量：17
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中国综合临床
2009年 第12期

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