摘要
目的探讨尿毒症患者血管钙化发生的相关因素。方法85例尿毒症患者，均行颈总动脉B超检查及胎球蛋白A、血磷、血钙、C-反应蛋白等检测。结果有血管钙化的尿毒症患者胎球蛋白A水平明显低于无钙化者[（2．34±0．95）μg/L与（3．79±1．19）μg／L，t=5．94，P〈0．01]，而血磷、钙磷乘积及C-反应蛋白水平高于非钙化组[血磷：（1．97±0．23）mmol／L与（1．80±0．33）mmol／L，t=2．05，P〈0．05；钙磷乘积：（50．04±6．61）mg2／dl2与（44．84±9．75）mg2／dl2，t=2．05，P〈0．05；C-反应蛋白：（33．45±25．11）mmo]／L与（20．65±13．43）mmoI／L，t=2．03，P〈0．05]。相关性分析显示胎球蛋白A水平与C-反应蛋白（r=-0．43，P〈0．01）、血钙磷乘积（r=-0．32，P〈0．01）、血白蛋白（r=0．37，P〈0．05）及血磷（r=-0．36，P〈0．05）相关。结论高血磷、钙磷乘积升高和微炎症状态是尿毒症患者血管钙化的危险因素，血胎球蛋白A水平降低导致尿毒症患者血管钙化，补充外源性胎球蛋白A可能成为一种预防血管钙化的有效手段。
Objective To investigate the factors relevant to the vascular calcification in uiemic patients . Methods Eighty-five uiemic patients were enrolled in this study. The levels of fetuin-A, serum calcium, serum phosphorus, C-reactive protein and other parameters related to calcification were examined . B-ultrasound was used to detect carotid plaques . Results The Fetuin-A levels in patients with vascular calcification were significantly lower than those with non-vascular calcification[ （2.34 ±0.95 ）μg/L vs （ 3.79±1.19） μg/L,t = 5.94, P 〈0.01 ] ,but serum calcium, serum phosphorus and C-reactive protein were higher than those non-vascular calcification [ serum phosphorus （ 1.97 ± 0.23 ） mmol/L vs （ 1.80±0. 33 ） mmol/L, t = 2.05, P 〈 0.05 ; calcium and phosphorus product （50.04 ±6.61 ） mg2/dl2 vs （44.84± 9.75 ） mga/dl2, t = 2.05, P 〈 0.05 ; C-reactive protein （ 33.45±25. 11 ） mmol/L vs（20.65±13.43 ） mmol/L, t = 2.03, P 〈 0.05 ]. Linear correlation analysis indicated that low fetuin-A level was correlated with C-reactive protein （ r = - 0.43, P 〈 0.01 ） , calcium-phosphorus product （ r = - 0.32, P 〈 0.01 ）, serum albumin concentration （ r = 0.37, P 〈 0.05 ） and phosphorus level （ r = - 0.36, P 〈 0.05 ）. Conclu- sions The risk factors relevant to the vascular calcification are high serum phosphorus, calcium and phosphorus product and the micro-inflammatory status in uiemic patients. Vascular calcification is also correlated with low fetuin- A level, adding exogenous Fetuin-A may become an effective means in preventing vascular calcification.
出处
《中国综合临床》
2009年第12期1273-1275,共3页
Clinical Medicine of China
关键词
尿毒症
血管钙化
血磷
血钙
C-反应蛋白
Uremia
Vascular calcification
Serum phosphorus
Serum calcium
C-reactive protein
