摘要
目的评价大剂量碘化油经肝动脉化疗栓塞(TACE)对兔VX2肝移植瘤生长及转移的影响。方法48只荷VX2肝移植瘤兔随机分成三组,每组16只。A组为对照组:经肝动脉灌注0.5ml生理盐水;B组为常规剂量碘化油TACE组(常规剂量组):经肝动脉灌注5mg阿霉素与常规剂量碘化油的混悬液;C组为大剂量碘化油TACE组(大剂量组):经肝动脉灌注5mg阿霉素与大剂量碘化油的混悬液。B组和C组碘化油用量(ml)分别为肿瘤体积(cm3)乘以0.5和1。经股动脉穿刺插管,依分组情况行介入治疗,比较不同处理组肝移植瘤TACE后2周的增长率、坏死率及肝内转移、肺转移的发生率。结果介入治疗前各组肿瘤平均体积之间无显著性差异(P>0.05);介入治疗后常规剂量组及大剂量组肿瘤增长率明显降低(P<0.01),大剂量组肿瘤增长率降低更为明显(P<0.01);与常规剂量组肿瘤的坏死率相比,大剂量组肿瘤的坏死率明显增加(P<0.01);大剂量组肿瘤肝内转移、肺转移的发生率明显降低(P<0.05)。结论大剂量碘化油TACE能明显抑制兔VX2肝移植瘤的生长与转移。
Objective To evaluate the effect of transcatheter arterial chemoembolization （TACE） with high-dose iodized oil on hepatic tumor growth and metastasis in rabbits. Methods Forty-eight rabbits with implanted VX2 tumor were randomly divided into control group, routine dose iodized oil TACE group and high-dose iodized oil TACE group to receive perfusion through the hepatic artery with 0.9% saline, 5 mg adriamycin with routine-dose iodized oil, and 5 mg adriamycin with high-dose iodized oil, respectively. The tumor volume, tumor necrosis, intrahepatic and lung metastasis were examined 2 weeks after TACE. Results No significant difference was found in the tumor volume between the 3 groups before TACE （P〉0.05）. The rabbits receiving TACE with iodized oil, especially at the high dose, showed significantly reduced tumor volume as compared with the control group （P〈0.01）. TACE with high-dose iodized oil resulted in significantly increased tumor necrosis rate in comparison with the control group and TACE with a routine dose of iodized oil （P〈0.05）; high-dose iodized oil TACE was also associated with reduced intrahepatic and lung metastasis as compared routine dose iodized oil TACE （P〈0.05）. Conclusion TACE with high-dose iodized oil can obviously inhibit the growth and intrahepatic and lung metastasis of transplanted VX2 liver tumor in rabbits .
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第10期2084-2087,共4页
Journal of Southern Medical University
关键词
碘化油
栓塞
肝癌
转移
iodize oil
embolization
liver cancer
metastasis
