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核纤层蛋白Lamin A的结构及功能和代谢特征 被引量：1

Structure,function,and metabolism of Lamin A
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摘要 Lamin A是细胞核内重要的骨架蛋白,对维持细胞的形态结构具有重要作用。文章综述了LMN A基因在染色体的位置lamin A蛋白质的形态、结构;LMN A基因不同位点的突变和缺失时机体产生的不同疾病;核纤层蛋白lamin A参与成肌细胞的分化作用功能;Caspase-6可促进核纤层蛋白lamin A的裂解以及NFAT5可能促进lamin A的表达等调节作用。 Abstract： Lamin A, which is an important skeleton protein in the cell nucleus, can play an important role in maintaining the morphological structures of the cells. This article summarizes the location of LMNA gene in the chromosome, the shape and the structure of lamin A protein; the different diseases of the body which result from the mutations and deletions of LMNA gene in different sites; the differentiation functions of myoblast in which lamin A is involved; degradation of lamin A that may be promoted by Caspase-6; the expression of lamin A that may be promoted by NFAT5.
作者 马延超 许寿生 周越 王瑞元
机构地区 洛阳师范学院体育学院 北京体育大学
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2009年第46期9167-9170,共4页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 国家自然科学基金课题(30570896)~~
关键词 LAMINA 功能 代谢
分类号 R318 [医药卫生—生物医学工程]
  • 相关文献

参考文献29

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共引文献22

同被引文献16

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中国组织工程研究与临床康复
2009年 第46期

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